摘要
目的:初步探讨牙周炎、慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)对血清白细胞介素17(interleukin-17,IL-17)表达的影响。方法:根据COPD、牙周炎的诊断标准选择单纯COPD病人91例,单纯牙周炎病人74例,COPD伴牙周炎病人73例作为病例组,健康者42例作为对照组,对每位受试者进行牙周检查、肺功能检查,采用酶联免疫吸附法(ELISA)测定4组受试者血清中IL-17、IL-1、IL-6、TNF-α的浓度。结果:单纯牙周炎组、COPD组血清IL-17水平的升高与对照组之间的差异有统计学意义(P<0.05),牙周炎伴COPD组血清IL-17水平的升高与单纯牙周炎组、单纯COPD组之间的差异有统计学意义(P<0.05)。单纯牙周炎组血清中IL-17水平与IL-6、PD、AL呈正相关,相关系数r与P值分别为0.426,0.012;0.537,0.039;0.545,0.001。牙周炎伴COPD组血清中IL-17水平与IL-6、PD、AL呈正相关,相关系数r与P值分别为0.386,0.010;0.637,0.011;0.762,0.036。结论:血清中IL-17的水平的高表达可能与牙周炎及COPD的发病机理有关;对于牙周炎病人,这种作用可能与其促进IL-6产生有关。
AIM：To analyze the effects of periodontitis and chronic obstructive pulmonary disease（COPD）on serum IL-17 levels.METHODS：91 patients with COPD,74 patients with periodontitis,73 patients with both diseases and 42 healthy people were enrolled in this study.Periodontal examinations and pulmonary function tests were performed on each subject.Serum levels of IL-17,IL-1,IL-6 and TNF-α were measured by enzyme-linked immuno-sorbent assay （ELISA）.RESULTS：Serum levels of IL-17 in periodontitis group and COPD group were significantly higher than the control group （P0.05）.Serum levels of IL-17 in patients with both diseased were significantly higher than that of simple periodontitis or COPD group （P0.05）.There was also a positive correlation between the serum levels of IL-17 and IL-6,periodontal depth and attachment loss,in patients of periodontitis group and in patients of both diseases group.CONCLUSION：Serum levels of IL-17 can reflect the health status of periodontal tissue to a certain extent.Its high expression may be involved in the pathogenesis of periodontitis and COPD.For the periodontitis patients,this effect may be related to its promotion of IL-6.
出处
《牙体牙髓牙周病学杂志》
CAS
北大核心
2010年第4期183-186,212,共5页
Chinese Journal of Conservative Dentistry
基金
国家自然科学基金资助项目(30872878)
北京市朝阳区科技计划项目(SF0810)
作者简介
作者简介：赵倩（1980-），女，汉族，河北人。硕士，医师
通讯作者：王左敏，Tel：010-85231492
