摘要
目的:探讨2型糖尿病(2-DM)合并非酒精性脂肪肝(NAFLD)的危险因素。方法:156例住院2-DM患者,根据腹部B超结果分为合并NAFLD组77例,不合并NAFLD组79例,将以上2组资料与46例单纯NAFLD患者(对照组)进行比较,分析2-DM合并NAFLD患者的临床特征及危险因素。结果:单纯NAFLD组体质量指数(BMI)、血尿酸(UA)、三酰甘油(TG)较2-DM合并NAFLD及不合并NAFLD组均显著增高(P均<0.05),而肾小球滤过率(GFR)则显著低于2组(P<0.05)。2-DM患者中,与不合并NAFLD组患者相比,合并NAFLD组患者有BMI、谷丙转氨酶(ALT)、谷草转氨酶(AST)、UA、TG、低密度脂蛋白(LDL)、载脂蛋白B(apoB)的显著增高(P均<0.05),高密度脂蛋白(HDL)、载脂蛋白A(apoA)、GFR显著降低(P均<0.05)。Logistic回归分析显示:BMI升高、HDL降低、UA升高是2-DM合并NAFLD的危险因素(P均<0.05)。结论:2-DM患者合并NAFLD与高BMI、高UA、血脂紊乱相关。
Objective To analyze the clinical characteristics and risk factors of type Ⅱ diabetes complicated with NAFLD. Methods A total of 156 type Ⅱ diabetes （2-DM） patients were categorized into with fatty liver group （n=77） and without fatty liver group （n=79） by ultrasonography,46 patients without diabetes but with NAFLD were served as control. Compared the clinical characteristics and analyzed the risk factors of type Ⅱ diabetes complicated with NAFLD. Results Compared with 2-DM patients,the control group had higher BMI,UA,TG,but lower GFR （P〈0.05）. Of the patients with 2-DM,those complicated with NAFLD had higher levels of BMI,TG,LDL,apoB,ALT,AST,UA （P〈0.05） and lower levels of HDL,apoA,GFR （P〈0.05）. Logistic regression analysis showed that high BMI,low HDL and high UA were the risk factors of 2-DM complicated with NAFLD （P〈0.05）. Conclusions High levels of BMI,UA and disorder of blood lipids contribut the incidence of NAFLD in 2-DM patients.
出处
《诊断学理论与实践》
2010年第2期194-197,共4页
Journal of Diagnostics Concepts & Practice
关键词
2型糖尿病
非酒精性脂肪肝
危险因素
Type Ⅱ diabetes mellitus
Non-alcoholic fatty liver disease
Risk factors
作者简介
通讯作者：薛冠华E-mail：Guanhuaxue@yeah．net
