摘要
目的探讨早期死亡的多发性骨髓瘤患者预后不良因素。方法对79例多发性骨髓瘤患者中的14例早期死亡(诊断后6个月内)临床资料进行回顾性分析,对这14例的临床和实验室指标进行单因素和多因素分析。结果单因素发现血β2-微球蛋白(β2-MG)、血乳酸脱氢酶(LDH)、血清蛋白水平、血肌酐和原始幼稚浆细胞比例是早期死亡的预后不良因素。多因素分析中确定只有血清蛋白水平、血肌酐、原始幼稚浆细胞比例、β2-MG和LDH是早期死亡的高危因素。结论高血β2-MG、高比例的原始及幼稚浆细胞、高LDH、低血清蛋白和肾功能不全被认为是早期死亡的预后不良因素。
Objective To discuss the prognosistic factors of the patients died in earlier stage with multiple myeloma. Methods Clinical data of 79 patients with MM were discussed retrospectively,and relative data of 14 patients died in earlier stage were assayed by single-and multi-factor analysis. Results The results of single-factor analysis showed that level of β2-MG, LDH, AI.B and Scr, and ratio of plasma cell were positively related with the early died patients; moreover, the results of multi factor analysis showed that the above index was high-risk factors in patients died in earlier stage. Conclusion Higher plasma level of β2-MG,LDH and Set,higher ratios of plasma cell in BM,and lower AI.B were regarded as negative prognosistic factors in early died MM patients.
出处
《检验医学与临床》
CAS
2010年第10期929-930,共2页
Laboratory Medicine and Clinic
关键词
早期死亡
多发性骨髓瘤
预后
died in earlier stage
multiple myeloma
prognosis
