摘要
目的探讨组织工程中细胞与材料粘附作用及其影响因素。方法广泛查阅近期有关细胞与材料粘附作用的文献，综述了组织细胞与材料作用方面的研究工作。结果细胞对材料的粘附特性不仅取决于材料本身，包括材料及其表面性质、表面修饰、表面形态、净电荷、孔隙率及降解速率，而且与细胞表面的分子表达及其材料的相互作用有关。结论定量测定细胞与材料的粘附作用并了解其生物物理机制在组织工程学研究中十分重要。
Objective To investigate the adhesive interactions of cells with materials and the effects of material properties on cell adhesion in tissue engineering. Methods By looking up the recent literatures dealt with adhesive interactions of cells with materials and reviewing previous work on the adhesion of tissue derived cells to materials.Results The adhesion characteristics of cells to materials not only depend on the nature of materials, including bulk and surface properties, surface modification, surface morphology, net charge, porosity and degradation rate, but also on the expression of cell surface molecules and their interaction with the material. Conclusion The quantitative measure and biophysical mechanisms of cell adhesion to materials might be very important in tissue engineering.
出处
《中国修复重建外科杂志》
CAS
CSCD
1999年第1期31-37,共7页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金
国家教育部生物力学及生物流变学开放实验室开放课题基金
关键词
细胞
粘附
材料
组织工程
Cell adhesion Materials Tissue engineering
