摘要
目的:评价齐拉西酮与氯氮平对首发住院精神分裂症患者社会功能和生活质量的影响。方法:79例精神分裂症患者随机分为齐拉西酮组40例与氯氮平组39例,分别给予口服齐拉西酮与氯氮平治疗12周。以阳性和阴性症状量表(PANSS)、副反应量表(TESS)、社会功能缺陷量表(SDSS)及生活质量综合评定问卷(GQOLI-74)分别评定2组患者的疗效、不良反应、社会功能缺陷和生活质量。结果:治疗后,2组的PANSS总分和各因子分均显著下降(P<0.05,0.01),齐拉西酮组阴性症状评分低于氯氦平组(P<0.01);SDSS各条目评分2组均明显下降(P<0.05,0.01),齐拉西酮组在家庭内外活动、对外界兴趣、社会性退缩、婚姻职能、责任心和计划性6个条目评分明显低于氯氮平组(P<0.05,0.01);齐拉西酮组的GQOLI-74总分及躯体维度、心理维度、社会功能维度评分明显高于氯氮平组(P<0.01);齐拉西酮组的不良反应发生率明显小于氯氮平组(37.5%与66.7%,P<0.01)。结论:齐拉西酮的疗效与氯氮平相当,但副作用小;对患者社会功能和生活质量的改善更明显。
Objective：To evaluate the influence of ziprasidone hydrochioride vs clozepine on the social function and quality of life in the first episode of patients with schizophrenia.Methods：Seventy-nine patients with schizophrenia were randomly divided into ziprasidone group（n=40）and clozepine group（n=39）receiving treatments of 12 weeks.Both groups were assessed with Positive and Negative Syndrome Scale（PANSS）,Treatment Emergent Symptoms Scale（TESS）,Social Disability Screening Schedule（SDSS）and Generic Quality Of Life Inventory-74（GQOLI-74）respectively to evaluate their efficacy,side effects,social function and quality of life.Results：Pre-and post-treatments,the scores of PANSS and each factor in both groups were decreased significantly（P0.01）,and no significant differences were found between two groups,except the negative syndrome（P0.05）.Occurrence frequency or severe degree in the side effects was lower in ziprasidone group than in clozepine group（P0.01）.The scores of each factor of SDSS in two groups were significantly decreased（P0.01）,but there were significant differences（P0.05,0.01）in the social activities outside family and inside family,marriage function,social withdrawal,interests to the environment,responsibility and plan between two groups.The total scores of GQOLI-74 and factor score in dimensions of physical health,psychological health and social functions in ziprasidone group were increased significantly as compared with clozepine group,but no significant difference was found in clozepine group after treatments.Conclusion：As compared to clozepine,ziprasidone hydrochioride has similar efficacy and less side effects in the patients with schizophrenia,and ziprasidone could improve the social function and quality of life more significantly than clozepine.
出处
《中国康复》
2010年第2期156-158,共3页
Chinese Journal of Rehabilitation
作者简介
段武钢（1964-），男,副主任医师，主要从事精神病学临床医疗方面的研究。
