摘要
哺乳动物受精是由一系列有序步骤组成的复杂细胞相互作用过程组成,最终导致精卵质膜融合形成受精卵。近来运用基因组学和蛋白质组学技术在哺乳动物精子和卵子表面鉴定出若干可能参与精卵质膜粘附与融合过程的蛋白分子,并对其结构和生物学功能进行了研究,但精卵识别与融合的分子机理仍然不清楚。综述了与精卵识别和融合有关的蛋白的最新研究进展,为进一步研究精卵相互作用的分子机制提供参考。
Fertilization is a multi-step process that culminates in the fusion of the sperm and egg membranes and formation of a zygote. A number of molecules with putative roles in sperm-oocyte fusion have been identified with genomic and proteomic techniques and their roles in the sperm-egg interaction have been studied. However,the mechanisms by which acrosome-reacted spermatozoa bind to receptor molecules on the oocyte plasma membrane and the subsequent fusion with the oolemma remain unknown. This article presented a detailed review of sperm-egg recognition and sperm-egg membrane interactions,which is of practical significance for deeper insights into the mechanisms of sperm-egg fusion.
出处
《生物技术通报》
CAS
CSCD
北大核心
2010年第5期38-42,54,共6页
Biotechnology Bulletin
基金
国家基础科学人才培养基金项目(J0730648)
国家大学生创新性实验计划项目(081012607)
关键词
精子
卵子
受精
精卵融合
Sperm Egg Fertilization Sperm-egg fusion
作者简介
作者简介：谷辰，男，研究方向：生物技术；E-mail：guchenbi088@126．com.
通讯作者：邢万金，男，教授，研究方向：哺乳动物生殖生物学与生物技术；E-mail：xwanjin@imu．edu．cn
