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PTEN基因与肿瘤的研究进展 被引量:4

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出处 《广东医学》 CAS CSCD 北大核心 2010年第7期920-923,共4页 Guangdong Medical Journal
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  • 1PLANCHON S M,WAITE K A,ENG C.The nuclear affairs of PTEN[J].J Cell Sci,2008,121(Pt3):249-253.
  • 2STILES B,WANG Y,STAHL A,et al.Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity[corrected].Proc Natl Acad Sci U S A,2004,101(7):2082-2087.
  • 3STILES B L.Phosphatase and tensin homologue deleted on chromosome 10:Extending its PTEN tacles[J].Int J Biochem Cell Biol,2009,41(4):757-761.
  • 4WENG L P,GIMM O,KUM J B,et al.Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependentcell death[J].Hum Mol Genet,2001,10(3):251-258.
  • 5WAITE K A,ENG C.Protean PTEN:form and function[J].Am J Hum Genet,2002,70(4):829-844.
  • 6HAMADA K,SASAKI T,KONI P A,et al.The PTEN/PI3K pathway Governs normal vascular development and tumor angiogenesis[J].Genes Dev,2005,19(17):2054-2065.
  • 7MEUILLET E J,MAHADEVAN D,BERGGEREN M,et al.Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase ativity and membrane binding:a mechanism for the functional loss of PTEN's tumor suppressor activity[J].Arch Biochem Biophys,2004,429(2):123-133.
  • 8GOBERDHAN D C,WILSON C.PTEN:tumour suppressor,multifunctional growth regulator and more[J].Hum Mol Genet,2003,12(2):239-248.
  • 9FURUKAWA K,KUMON Y,HARADA H,et al.PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules[J].Int J Oncol,2006,29 (1):73.
  • 10ABE T,TERADA K,WAKIMOTO H,et al.PTEN decrease in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli[J].Cancer Res,2003,63 (9):2300.

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