摘要
目的:通过动物实验探讨人参皂苷联合地塞米松的抗运动病作用。方法:将50只SD大鼠随机分为生理盐水组(阴性对照)、东莨菪碱组(阳性药物对照)、地塞米松组、人参皂苷组和人参皂苷联合地塞米松组。各组大鼠予以相应药物灌喂0.5 h后进行加速度暴露1 h,观测异嗜高岭土量、晕反应指数、旷场自发活动量以及体质量变化情况。结果:与生理盐水组相比,在1 h×3 d加速度刺激后,人参皂苷联合地塞米松组大鼠异嗜高岭土量和晕反应指数评分明显降低,旷场自发活动量明显增加;与地塞米松组相比,人参皂苷联合地塞米松组大鼠体质量下降的幅度明显减小。结论:人参皂苷联合地塞米松可明显增强大鼠对异常加速度的耐受能力,并可缓解单独服用地塞米松所致实验大鼠体质量负增长的幅度。
Objective：To investigate the antimotion sickness effects of ginsenosides combined with dexamethasone in rats. Methods：Fifty SD rats were randomly divided into 5 groups：normal saline,scopolamine-treated, ginsenosides-treated,dexamethasone-treated and ginsenosides plus dexamethasone-treated groups.There were 10 rats in each group.The rats in each group were fed with corresponding ingredients respectively,and then the rats were exposed to abnormal acceleration for one hour.The motion sickness index,the level of kaolin consumption and the course and time of spontaneous activity were observed. Results：The motion sickness index and the level of kaolin consumption of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly lower than those in normal saline group. And the course and time of spontaneous activity of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly higher than those in normal saline group.The level of body weight increment of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group was significantly higher than that in dexamethasone-treated group. Conclusion：Ginsenosides combined with dexamethasone can significantly increase tolerance to acceleration of rats,and the drug combination can decrease side effects of methylprednisolone,such as body weight loss.
出处
《中西医结合学报》
CAS
2010年第4期358-362,共5页
Journal of Chinese Integrative Medicine
作者简介
Correspondence： Min LI, MD, Professor; Tel 021-81871120; E-mail： linlimin115@hotmail.com
