摘要
目的探讨成人脂肪肝患者与非脂肪肝患者血常规的差异。方法选用沈阳地区2008年3月～2008年12月参加体检的18岁以上人群为研究对象,对肝脏彩色多普勒检查诊断的脂肪肝与非脂肪肝患者,采用问卷咨询、体格检查和生化检查外,重点探讨脂肪肝与血常规之间的关系,数据用SPSS16.0软件分析。结果入选人群共8842名,B超共检出脂肪肝3306例,占37.39%,其中酒精性、非酒精性脂肪肝分别占15%(1326名)和22.39%(1980名),与非脂肪肝组(NAFL)相比,脂肪肝组(AFL)WBC(白细胞计数)、EO%(嗜酸性细胞比率)、RBC(红细胞计数)、HGB(血红蛋白浓度)、HCT(红细胞比积测定)、MCH(平均红细胞Hb含量)、MCHC(平均红细胞Hb浓度)、RDW(红细胞分布宽度)、PDW(血小板分布宽度)显著增加(P<0.01);LYM%(淋巴细胞比率)、MONO%(单核细胞比率)、MCV(平均细胞容积)、P-LCR(大型血小板比率)、MPV(平均血小板体积)等明显增加(P<0.05);PLT(血小板计数)明显减少(P<0.05);与非酒精性脂肪肝组(NAFL)比,酒精性脂肪肝(AFL)组RBC、HGB、HCT、MCV、MCHC等显著增加(P<0.01),LYM%明显减少(P<0.05),MCH、MONO%(单核细胞比率)明显增加(P<0.05)。结论脂肪肝患者中白细胞总数及分类(除中性粒细胞百分比外)明显高于非脂肪肝组,红细胞系统(除MCHC外)也有类似的趋势,而血小板计数明显低于非脂肪肝组;而酒精性和非酒精性脂肪肝相比,红细胞系统显著增加,尤其MCV更加明显,而白细胞系统(除LYM%明显减少外)和血小板系统大部分无显著变化。说明简单的血常规及分类检查对脂肪肝的临床诊断和病因诊断具有重要的意义。
Objective To investigate the differences of the blood routine indexes in patients with fatty liver and non-fatty liver.Methods Objects include adults who participated in physical examination in Shenyang between March,2008 and Dec,2008.For those with fatty liver and non-fatty liver found by ultrasonography,we mainly focus on the relationship between the fatty liver and blood routine indexes besides the use of the consultation questionnaire,physical examination and biochemistry,.The data was analyzed with spss16.0.Results Of the 8842 subjects,the incidence of fatty liver is 37.39% （3306） with alcoholic fatty liver 15%（1326）and non-alcoholic fatty liver22.39% （1980） respectively.Compared with the non-fatty liver group,WBC （white blood cell count）,EO% （eosinophil ratio）,RBC （red blood cell count）,HGB （hemoglobin concentration）,HCT （hematocrit determination）,MCH （mean corpuscular Hb concentration）,MCHC （mean corpuscular Hb concentration）,RDW （red blood cell distribution width ）,PDW（platelet distribution width）were markedly increased （P0.01） in the fatty liver group;LYM% （lymphocyte ratio）,MONO% （the ratio of mononuclear cells）,MCV（mean corpuscular volume）,P-LCR （the ratio of large platelets）,MPV （mean platelet volume）were significantly increased （P0.05）;while PLT（platelet count）was significantly reduced （P0.05）;Compared with the non-alcoholic fatty liver group,RBC,HGB,HCT,MCV,MCHC were significantly increased （P0.01）;LYM% was significantly reduced （P0.05）;MCH,MONO% was significantly increased （P0.05） in the alcoholic fatty liver group.Conclusion Compared with the non-fatty liver group,the total number and differential count （except the percentage of neutrophils）of leukocytes in patients with fatty liver were significantly higher with a similar trend for erythroid cells （except MCHC）,while the platelet count was significantly reduced.Moreover,a significant increase in erythroid cells （especially in MCV）was observed in alcoholic fatty liver group compared to the non-alcoholic fatty liver group,while no significant differences were obtained in the leukon and platelets system except a decrease in LYM%.These fully explained the significant importance of blood routine test as well as differential count for the etiological and clinical diagnosis of fatty liver.
出处
《临床肝胆病杂志》
CAS
2010年第2期163-166,共4页
Journal of Clinical Hepatology
基金
辽宁省教育厅科技攻关项目(编号:2007225011-1)
关键词
脂肪肝
酒精性脂肪肝
非酒精性脂肪肝
血常规
fatty liver
alcoholic fatty liver
non-alcoholic fatty liver
blood routine test
作者简介
秦永军（1982-），男，硕士研究生，研究方向：脂肪性肝病。
通信作者：王炳元，E-mail：wangby@medmail．com．cn
