摘要
目的探讨大蒜素治疗病毒性心肌炎(VMC)的疗效及其机制。方法选择符合诊断标准的96例VMC患者,随机分为三组。A组32例,予常规西药治疗,B组32例在A组基础上加用黄芪注射液治疗,C组在A组基础上加用大蒜素注射液治疗,三组疗程均为30 d,观察治疗前后患者心律失常率、ST-T改变率及心脏肌钙蛋白T(cTnT)、肌酸激酶同工酶(CK-MB)和白细胞介素18(IL-18)检测水平的变化情况。结果三组患者治疗后其心律失常率、ST-T改变率、cTnT和CK-MB均显著下降(P<0.01),A、B、C三组各观察指标有逐级改善趋势,C组改善幅度最大(P<0.01)。C组患者治疗7、15、30 d后其血清IL-18水平均显著下降(P<0.01),A、B组患者治疗15、30 d后其血清IL-18水平均显著下降(P<0.05或0.01),A、B、C三组患者治疗15、30 d后其血清IL-18水平有逐级下降趋势(P<0.01),C组下降幅度最大(P<0.01)。结论大蒜素对VMC患者有良好的治疗效果,可能与其抑制病毒复制,恢复被病毒破坏的细胞免疫系统功能,减轻患者的免疫反应对其心肌的损伤,从而改善患者临床症状和心功能有关。
Objective To explore the curative effect of garlicin on the treatment of viral myocarditis （VMC）and its mechanism. Methods 96 patients with VMC were randomly divided into three groups, group A of 32 patients were given western conventional medicine,group B of 32 patients were given astragalus injection besides the conventional therapy,while group C were given garlic injection. The course in three groups were 30 days. The incidence of the arrhythmia,st-t segment changes and the level of cTnT,CK-MB, IL-18 in patients were observed before and after the treatment. Results The incidence of the arrhythmia,st-t segment changes and the level of cTnT,CK-MB,IL-18 decreased significantly in all the patients After treatment（ P 〈0.01）. and the observation indexes improved at the same time,especially the group C（ P〈0.01）. the level of serum IL-18 decreased significantly in the 7th, 15th and the 30th day after treatment in group C （ P 〈0.01）, while the level decreased significantly in the 15thand the 30th day after treatment in group A and B （ P 〈0. 05 or 0. 01 ）. descent range of group C was the largest amongst these three groups （ P 〈0.01）. Conclusion There is good curative effect of garlicin on the treatment for VMC. This may related to the inhibition of virus replication,recovery of the cellular immunity and reduction of the injury of cardia musle by immunological reaction,and this improve the patient＇s clinlcal symptom and heart function.
出处
《右江医学》
2010年第2期120-122,共3页
Chinese Youjiang Medical Journal
基金
2001年广西科技厅资助项目(合同编号:桂科基0141029)
作者简介
潘兴寿（1967-），男（壮族），广西德保县人，副主任医师，医学学士。
