摘要
Tumor necrosis factor-α (TNF-α) plays a key role in the pathogenesis of experimental autoimmune neuritis (EAN) as well as Guillain-Barre syndrome. The proposed pathogenesis of TNF-α associated neuropathies involves immune-mediated attack to blood-nerve barrier, aggravated production of pro-inflammatory cytokines, and the induction of Schwann cells apoptosis. TNF-α may play a regulatory role by increasing production of interleukin-1 in macrophages, attenuating T cell receptor signaling and regulating apoptosis of potentially autoreactive T cells in EAN. The data suggest that antagonizing TNF-α functions or suppressing TNF-α production may be useful in the acute phase of EAN treatment, but further studies are required.
Tumor necrosis factor-α(TNF-α)plays a key role in the pathogenesis of experimental autoimmune neuritis(EAN)as well as Guillain-Barre syndrome.The proposed pathogenesis of TNF-αassociated neuropathies involves immune-mediated attack to blood-nerve barrier,aggravated production of pro-inflammatory cytokines,and the induction of Schwann cells apoptosis.TNF-αmay play a regulatory role by increasing production of interleukin-1 in macrophages,attenuating T cell receptor signaling and regulating apoptosis of potentially autoreactive T cells in EAN.The data suggest that antagonizing TNF-αfunctions or suppressing TNF-αproduction may be useful in the acute phase of EAN treatment,but further studies are required.
作者简介
Xijing Mao,M.D.,Department of Neurology,First Hospital of Jilin University,Changchun 130021,Jilin Province,China;Department of Neurobiology,Care Sciences and Society,Karolinska Institute,Karolinska University Hospital Huddinge,Stockholm,Sweden Corresponding author:Jie Zhu,M.D.,Associated professor,Department of Neurology,First Hospital of Jilin University,Changchun 130021,Jilin Province,China;Department of Neurobiology,Care Sciences and Society,Karolinska Institute,Karolinska University Hospital Huddinge,Stockholm,Sweden J ie.Zh u@ki.se
