摘要
目的探讨脑梗死急性期血清炎性因子超敏C反应蛋白(hs-CRP)和基质金属蛋白酶-9(MMP-9)与脑梗死分型的关系。方法按TOAST及OCSP分型将72例急性脑梗死患者分为不同的亚组,检测各亚组患者的血清hs-CRP和MMP-9水平,并与42例健康者进行对照。结果脑梗死急性期患者血清hs-CRP水平高于对照组,MMP-9水平亦高于对照组,差异均有统计学意义(P<0.05)。按TOAST病因分型,大动脉粥样硬化型(LAA)脑梗死患者的血清hs-CRP和MMP-9水平均高于小动脉闭塞型(SAD)患者和对照者(P<0.05)。按OCSP分型,完全前循环梗死(TACI)、部分前循环梗死(PACI)、后循环梗死(POCI)患者的血清hs-CRP和MMP-9水平均高于对照者,差异有统计学意义(P<0.05)。结论血清炎性因子hs-CRP和MMP-9可协助脑梗死的病因分型和病情判断。
Objective To investigate the relationship of cerebral infarction （CI） acute-phase inflammation markers such as high-sensitive C-reactive protein （hs-CRP） and matrix metalloproteinase-9 （MMP-9） to CI typing.Methods Seventy-two acute CI patients were divided,according to Trial of ORG 10172 in Acute Stroke Treatment （TOAST） and Oxfordshire Community Stroke Project （OCSP）,into different sub-groups.Serum hs-CRP and MMP-9 levels were determined in all subgroups and compared with those of 42 healthy subjects.Results Serum hs-CRP and MMP-9 levels were higher in acute CI patients than in control,the difference was significant （P〈0.05）.According to TOAST,hs-CRP and MMP-9 levels were higher in large artery arteriosclerosis （LAA） CI patients than in small artery disease （SAD） CI patients and control group （P〈0.01）.According to OCSP,the levels of hs-CRP and MMP-9 were higher in patients with total anterior circulation infarct （TACI）,partial anterior circulation infarct （PACI）,or posterior circulation infarct （POCI） than in control group,the difference was significant （P〈0.05）.Conclusion Serum inflammatory markers is useful for aetiological typing and prognosis
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第8期831-833,共3页
Chinese General Practice
基金
北京市优秀人才培养专项经费(20051D0300102)
北京市卫生系统高层次卫生技术人才培养计划项目(2009-3-07)
关键词
脑梗死
超敏C反应蛋白
基质金属蛋白酶-9
分型
Ischemic stroke
High-sensitivity C-reactive protein
Matrix metalloproteinase-9
Classification
作者简介
通讯作者：张拥波，100050北京市，首都医科大学附属北京友谊医院神经内科；E—mail：ybzhangcn@sina．com
