摘要
目的探讨血液灌流(HP)对维持性血液透析患者血浆瘦素(Leptin)及营养状况的影响。方法将48例慢性肾衰竭(CRF)透析患者随机分成两组,血液灌流(HP)联合血液透析(HD)治疗组(HP+HD组)24例,单纯HD治疗组(HD组)24例,分别于治疗前后测定两组患者的血浆瘦素(Leptin)、前清蛋白(PA)、转铁蛋白(TRF)、清蛋白(Alb)及血红蛋白(Hb)的水平,对比两组的测定结果并分析各指标间的相关性。结果治疗前两组患者的血浆Leptin、PA、TRF、Alb及Hb的水平间差异均无统计学意义(P>0.05),治疗后HP+HD组患者的血浆Leptin水平明显降低,各营养指标明显改善,与HD组相比差异有统计学意义(P<0.05);血浆Leptin水平与PA、Alb水平呈负相关(P<0.05)。结论HP能有效清除Leptin,改善患者的营养状况;PA可能是反映早期CRF患者营养状况的指标之一。
Objective To research the effects of hemoperfusion （HD） on serum leptin and nutritional status in maintenance hemodialysis （MH） patients.Methods Forty-eight MH patients were divided randomly into groups HP and HP＋HD,24 in each.Serum leptin,pre-albumin（PA）,transferrin（TRF）,albumin（Alb） and haemoglobin （Hb） were detected in 2 groups before treatment and after 3 months of treatment.The results were determined to analyze the correlation between the indexes.Results There was not significant difference in Leptin,PA,TRF,Alb between 2 groups before treatment （P〉0.05）.Leptin level decreased remarkably and the nutrition indicators improved in HP＋HD group,the difference was significant between 2 groups （P〈0.05）.Leptin was negatively correlated with PA and Alb （P〈0.05）.Conclusion HP can remove effectively Leptin and improve patients＇ nutritional status.PA may be one of the indicators reflecting the nutritional status in early CRF patients.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第8期817-818,共2页
Chinese General Practice
关键词
血液灌流
肾透析
瘦素
营养不良
Hemoperfusion
Renal dialysis
Leptin
Malnutrition
作者简介
通讯作者：李德天，110004辽宁省沈阳市，中国医科大学附属盛京医院肾内科；E—mail：lidt@sj—hospital.org
