摘要
目的观察依达拉奉联合单唾液酸四己糖神经节苷酯(GM1)治疗大面积脑梗死的临床疗效。方法选择102例发病48 h内的急性脑梗死患者,随机分为2组。治疗前及治疗后7、14、30、90 d分别进行欧洲卒中评分(ESS)、Barthel指数量表(ADL)评分,判定疗效,计算有效率。结果治疗组总有效率56.6%,对照组32.7%,2组相比差异有统计学意义(P<0.01)。治疗组未见严重不良反应。结论依达拉奉联合神经节苷脂治疗急性大面积脑梗死安全有效。
Objective To observe the clinical efficacy of edaravone combined with GM1 on acute cerebral infarction of large area.Methods Total 102 patients with acute cerebral infarction of large area were randomly divided into two groups.One was the treatment group（n=53） which was treated with edaravone injection 30 mg in sodium chloride injection 250 ml,iv gtt,bid,accompanied by GM1 injection 80 mg in sodium chloride injection 250 ml,iv gtt,qd,for 14 days.The other was control group（n=49） which was treated with edaravone injection 30 mg in sodium chloride injection 250 ml,iv gtt,bid,accompanied by citicoline injection 0.75 g in sodium chloride injection 250ml,iv gtt,qd,for 14 days.All patients were administrated mannitol injection and hemodilution,and all of them received the examination of CT or MRI before and after the treatment.Before treatment and at 7th,14th,30th and 90th day after treatment,the neurological deficits and activities of daily living（ADL） were evaluated by European stroke scale（ESS） and Barthel index respectively.Results The recovery degree of nervous function in treatment group was much better than that of control group（P0.01）.Effective rates were 56.6% and 32.7% in the treatment group and control group respectively,with a significant difference between the two groups（P0.01）.No severe side-effect was detected in the treatment group.Conclusion The therapy of edaravone combined with ganglioside GM1 is effective and safe in treating acute cerebral infarction of large area.
出处
《中国实用神经疾病杂志》
2010年第4期24-26,共3页
Chinese Journal of Practical Nervous Diseases
