摘要
目的：研究高颅压下鞘内注射两性霉素Ｂ（ＡＭＢ）治疗隐球菌性脑膜炎的疗效与安全性。方法：２３例隐球菌性脑膜炎患者，鞘内注射组１１例，采用鞘内注射和同时静脉滴注ＡＭＢ，合用氟康唑或氟胞嘧啶。非鞘内注射组１２例，不采用鞘内注射治疗，其他治疗与鞘内注射组相同。结果：鞘内注射组全部治愈，未遗留后遗症。非鞘内注射组治愈７例，好转２例，死亡３例。结论：鞘内注射是抢救和治疗隐球菌性脑膜炎、缓解高颅内压。
Objective: To evaluate the efficacy and safety of intrathecal administration of amphotericin B(AMB) under high intracranial pressure in the treatment of cryptococcal meningitis. Methods: Of the 23 patients with cryptococcal meningitis, 11 received intrathecal AMB therapy combined with intravenous AMB or fluconazole and flucytosine, and 12 received intravenous AMB combined with fluconazole or flucytosine. Results: All the patients who received intrathecal AMB therapy were cured without any sequela. Of the 12 patients who did not received intrathecal AMB therapy, 7 were cured, 2 improved, and 3 died. Conclusion: The intrathecal AMB therapy may be a valuable approach in the treatment of cryptococcal meningitis by relieving high intracranial pressure and reducing severe sequela.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1998年第6期579-580,共2页
Academic Journal of Second Military Medical University
关键词
脑膜炎
隐球菌性
两性霉素B
鞘内注射
meningitis, cryptococcal
amphotericin B
intrathecal injection
