摘要
目的探讨白细胞介素-17(IL-17)、白细胞介素-18(IL-18)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)在类风湿关节炎(RA)患者外周血中的表达和临床意义。方法应用ELISA方法对40例活动期RA患者、40例稳定期RA患者和40例健康对照组的外周血血清中的IL-17、IL-18、IL-6和TNF-α含量进行检测分析。结果活动期RA患者的血清中IL-17、IL-18、IL-6和TNF-α含量明显高于稳定期RA患者(P<0.01)和健康对照组(P<0.01);稳定期RA患者的血清中IL-17和IL-18含量高于健康对照组(P<0.05),而IL-6和TNF-α含量与对照组相比,差异无统计学意义(P>0.05)。结论RA患者IL-17、IL-18、IL-6和TNF-α含量的变化特点与病情相关,联合动态监测有助于临床观察和治疗。
Objective To investigate the levels of IL-17, IL-18, IL-6, and TNF-α in serum from patients with rheumatoid arthritis （RA） and its clinical significance. Methods Levels oflL-17, IL-18, IL-6, and TNF-α in 80 patients with RA and 40 normal controls （NC） were measured by ELISA. Results The levels of IL- 17, IL- 18, IL-6, and TNF-α in active RA patients were significantly higher than those in stable RA and in NC. The levels ofIL-17 and IL-18 were significantly different between stable RA and NC. There were no difference in IL-6 and TNF- α levels between the two groups. Conclusion IL-17, IL-18, IL-6 and TNF- α are more sensitive index for detecting the activity of rheumatoid arthritis and may play an important role in monitoring the therapeutic effects and prognosis of RA.
出处
《当代医学》
2010年第7期13-14,共2页
Contemporary Medicine
