摘要
以聚[2,2′-(对氧基联苯)-5,5′-苯并咪唑](OPBI)及其磺化产物磺化聚[2,2′-(对氧基联苯)-5,5′-苯并咪唑](SOPBI)薄膜作为基体,采用交替沉积和模拟体液(SBF)浸泡相结合的方法快速在薄膜表面沉积羟基磷灰石层.采用选区电子衍射(SAED)和衰减全反射傅里叶变换红外光谱(ATR-FTIR)对羟基磷灰石(HA)的晶体结构进行了分析.用扫描电子显微镜(SEM)对整个沉积过程中羟基磷灰石的形态变化进行了跟踪.实验结果表明,SOPBI薄膜诱导HA沉积的速率明显快于OPBI薄膜.SOPBI的磺酸基团不但提供了固定Ca2+的负电表面,而且还有助于咪唑基团对Ca2+的固定.而缺失磺酸基团的OPBI在不同pH值的交替沉积溶液中的电离形式阻碍了咪唑基团对Ca2+和HPO24-的作用,且未能在SBF浸泡过程中得到改善.
Organic polymer coated with hydroxyapatite （HA） is an attractive material for the development of tissue repairing application. The abilities of hydroxyapatite incubation on poly [ 2,2＇-（p-oxydiphenylene）-5, 5 ＇-bibenzimidazole ] （ OPBI ） and sulfonated poly [ 2,2＇- （p-oxydiphenylene） -5,5 ＇-bibenzimidazole ] （ SOPBI ） membranes were investigated with the combination of alternate soaking process and simulated body fluid （SBF） soaking methods. Hydroxyapatite phase was analyzed by SAED and ATR-FTIR method. Morphology changes of the hydroxyapatite were observed by SEM. The results show that the use of the SOPBI membranes leads to a higher hydroxyapatite formation rate than that of the OPBI membranes. The sulfonic groups of SOPBI membranes not only offer a negative charged surface to attract Ca2＋ but also help imidazole groups to bind Ca^2＋. In comparison, OPBI membranes without sulfonic groups decrease formation ability of hydroxyapatite because protonation types of imidazole groups in alternate soaking solutions inhibit interaction between imidazole and Ca^2＋ and HPO2- , which can not be improved by the subsequent SBF soaking.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2010年第1期1-6,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:50973062)资助
关键词
羟基磷灰石
磺化聚醚苯并咪唑
交替沉积
Hydroxyapatite
Poly [2,2＇-（p-oxydiphenylene）-5,5＇-bibenzimidazole]
Alternate soaking
作者简介
联系人简介：史子兴，男，博士，副教授，主要从事聚合物基杂化材料和耐热杂环高聚物的设计与合成研究．E-mail：zxshi@sjtu．edu．cn
