摘要
综述定量核磁共振技术的基本原理以及在新药研发中的应用进展。定量核磁共振作为一种定量分析方法,专属性强、准确快捷,可与其他定量方法相互补充,用于新药研发的诸多环节,如药品质量控制、候选药物纯度测定及药物代谢研究等,在药学领域有很好的应用前景。
The principle of quantitative nuclear magnetic resonance （QNMR） technique and the advances in its applications within new drug R＆D were reviewed. As a well-developed quantitative analysis method, QNMR is of high specificity and accuracy. It can be used to complement with other quantita- tive methods in new drug R＆D, such as quality control of pharmaceuticals, purity determination of drug candidates, as well as the analysis of drug metabolites. It has a promising future in pharmaceutical field.
出处
《药学进展》
CAS
2010年第1期17-23,共7页
Progress in Pharmaceutical Sciences
关键词
定量核磁共振
质量控制
药物代谢物
新药研发
QNMR
quality control
drug metabolite
new drug research and development
作者简介
通讯作者：相秉仁，教授；研究方向：计算药物分析；Tel：025—83271180；E—mail：xiangbr@cpu．edu．cn
