摘要
目的回顾性分析171例肺癌脑转移的治疗，探讨其疗效及预后因素。方法收集2001年3月至2008年10月我科171例肺癌脑转移患者的资料。所有病例均采用了放射治疗，全脑放疗DT30～40Gy／10～20f，肿瘤数目≤2个者局部加量至DT56～60Gy／25～30f。其中103例接受放化联合治疗。生存率计算采用Kaplan—Meier法，生存差异比较采用Log—rank检验，多因素分析采用Cox比例风险模型。结果全组患者中位生存期8．6个月。1年和2年生存牢分别为28．7％、9．4％。多因素分析表明：颅外有无转移性病灶、脑转移灶数目和是否合并化疗足患者的独立预后因素。结论肺癌发生脑转移后应用放射治疗可减轻患者临床症状，延长生命。颅外有无转移性病灶、脑转移灶数日和是否合并化疗可作为患者的预后因素。
Objective Through retrospective analysis of the treatment of 171 cases of lung cancer patients with brain metastasis, we investigated its curative effect and prognostic factors. Methods From March 2001 to October 2008,171 cases of lung cancer patients wiLh brain metastasis were diagnosed and treated,whose clinical data were retrospectively reviewed. All patients received radiotherapy with whole brain irradiation to DT30 - 40 Gy/10 -20 fractions,while the dose was boosted to DT56 - 60 Gy/25 -30 fractions for the patients who had one or two lesions in the brain. 103 cases received chemotherapy combined with radiotherapy. Kaplan-Meier method was used to analyze the survival rate, log-rank was used to compare the difference between groups and multivariate analysis was performed by the Cox regression proportional hazard model. Results For all patients the median survival time was 8.6 months,while the 1-year and 2-year survival rate was 28.7% and 9.4% respectively. Multivariate analysis showed that the independent prognostic factors were as follows： ex- tracranial metastasis,combined with chemotherapy and brain metastasis numbers. Conclusion Radiotherapy should be performed for lung cancer patients with brain metastasis. This treatment may improve the clinical symptom and increase the survival time. Extraeranial metastasis, combined with chemotherapy and brain metastasis numbers, are independent prognostic factors.
出处
《临床肺科杂志》
2010年第2期163-165,共3页
Journal of Clinical Pulmonary Medicine
关键词
肺癌
脑转移
放射治疗
预后
lung cancer
brain metastasis
radiotherapy
prognosis
作者简介
通讯作者：钱立庭，E—mail：money2004@sina.com
