摘要
目的:研究以血浆药物浓度为目标输注咪达唑仑的准确性。方法:将自行研究所得的咪达唑仑参数通过C语言编写入单片机的靶控输注系统,以血浆药物浓度为目标输注完成12例择期手术患者的临床麻醉,比较咪达唑仑血药浓度实测值与预测值,计算咪达唑仑样本的执行误差(PE)、执行误差的绝对值(absPE)、执行误差的中位数(MDPE)、执行误差绝对值的中位数(MDAPE)、稳定误差(CE)、稳定误差的绝对值(absCE)、稳定误差的中位数(MDCE)、稳定误差绝对值的中位数(MDACE)。结果:血浆咪达唑仑浓度的预测误差PE、absPE、MDPE、MDAPE分别为-2.57%、14.16%、-3.28%、15.34%,患者个体内稳定误差CE、absCE、MDCE、MDACE分别为0.06%、1.42%、0.03%、1.21%,实测值与预测值呈正相关(r=0.986,P<0.05)。结论:应用自行研究所得咪达唑仑药动学参数行以血浆药物浓度为目标输注的精确度和稳定性较好。
OBJECTIVE： To study the accuracy of infusion of Midazoloam with plasma concentration as target. METHODS： The parameters of Midazoloam obtained from our researches were inputted into target-controlled infusion （TCI） system with C language. The clinical anesthesia of 12 patients undergoing selective operations was completed with plasma concentration as target-controlled infusion. Predicted value of plasma concentration of Midazoloam was compared with measured value. Parameters of Midazoloam sample were calculated such as performance error（PE）, absolute performance error（absPE）, median performance error（MDPE） , median absolute performance error（MDAPE） , constancy error（CE）, absolute constancy error（absCE） , median constancy error （MDCE） and median absolute constancy error （MDACE）. RESULTS： PE, absPE, MDPE and MDAPE of plasma concentration were --2.57%, 14.16%, --3.28% and 15.34%, respectively. CE, absCE, MDCE and MDACE were 0.06%, 1.42%, 0.03% and 1.21%, respectively. The measured values were in indirect relationship with predicated values （r=0.986, P〈0.05）. CONCLUSION： Plasma concentration target-controlled infusion applying pharmacokinetic parameters of Midazolam performs good stability and accuracy.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第2期125-127,共3页
China Pharmacy
基金
广州市科技计划项目(2007Z3-D0031)
关键词
咪达唑仑
目标输注
药动学
靶控输注系统
Midazolam
Target-controlled infusion
Pharmacokinetics
Target-controlled infusion system
作者简介
副主任医师，硕士研究生。研究方向：静脉麻醉药的靶控输注。电话：020—36655008。E—mail：xubo333@hotmail．com
