摘要
目的:观察平贝母水提物、雪花梨汁以及平贝雪梨饮(BLY)的抗炎作用及其作用机制。方法:通过二甲苯导致小鼠耳肿胀实验、鸡蛋清致大鼠足趾肿胀实验及对小鼠毛细血管通透性的影响分别观察平贝母水提物、雪花梨及BLY的抗炎作用,同时通过测定小鼠炎性渗出物中前列腺素(PGE2)和丙二醛(MDA)含量研究三者的抗炎机制。结果:三者均能减轻二甲苯所致的耳廓肿胀;能降低小鼠毛细血管通透性;能减轻鸡蛋清致大鼠足趾肿胀;能抑制小鼠炎性渗出物中PGE2和MDA含量的升高,且梨汁和BLY均与PGE2和MDA含量呈量效关系。结论:平贝母水提物和雪花梨汁都具有抗炎作用,同等剂量的BLY作用效果比平贝母水提物和雪花梨汁抗炎作用之和更为显著,三者对PGE2和MDA含量升高具有负调节作用,提示其抗炎作用与抗PGE2和MDA含量升高有关。
Objective：To investigate anti-inflammatory effects and action mechanisms of aqueous extract of Fritillaria ussuriensis Maxim.,snow pear juice and Pingbei Xueli Yin（BLY）.Methods：Animal models of auricular edema induced by xylene in mice,capillary permeability induced by acetic acid in mice and paw edema induced by albumen in rats were established to observe anti-inflammatory effects of aqueous extract of Fritillaria ussuriensis Maxim.,snow pear juice and BLY.The contents of PGE2 and MDA in inflammatory exudates were measured to explore anti-inflammatory mechanisms of three samples.Results：Aqueous extract of Fritillaria ussuriensis Maxim.,snow pear juice and BLY exhibited good attenuation effects on auricular edema induced by xylene,paw edema induced by albumen and permeability increase of capillary induced by acetic acid.Meanwhile,the three experimental samples revealed an obvious inhibition effect on the increase of PGE2 and MDA.Moreover,snow pear juice and BLY exhibited an obvious dose-dependent inhibition effect on the increase of PGE2 and MDA.Conclusion：All of them have a good anti-inflammatory effect.A synergistic effect of Fritillaria ussuriensis Maxim.and snow pear juice on anti-inflammation is achieved.The three administration samples all had a negative regulation function on the level of PGE2 and MDA,which suggests that the anti-inflammatory effect might be related to the reduction of PGE2 and MDA levels.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2010年第1期235-239,共5页
Food Science
关键词
平贝母水提物
雪花梨汁
平贝雪梨饮(BLY)
抗炎作用
aqueous extract of Fritillaria ussuriensis Maxim. snow pear juice BLY anti-inflammatory effect
作者简介
李霞（1979-），女，博士研究生，研究方向为天然产物药物化学。E—mail：lixia2008@tju．edu．cn
通信作者：高文远（1965-），男，教授，博士，研究方向为中药和天然药物新产品的研究以及中药和天然药物的质量控制。E-mail：pharmgao@tju．edu．cn
