摘要
目的通过研究当归贝母苦参丸(DBK)对小鼠前列腺增生(BPH)及性激素平衡的影响,为临床用药提供药理学研究依据。方法采用皮下注射丙酸睾酮制作去势小鼠前列腺增生模型,观察各组前列腺指数、性激素水平及腺细胞病理改变。结果DBK治疗14d后,与模型组相比,DBK组小鼠前列腺湿重及前列腺指数出现剂量依赖性降低(P<0.05或P<0.01),明显改善前列腺组织病理结构;血清丙酸睾酮(T)、雌二醇(E2)含量明显降低(P<0.05或P<0.01)。结论DBK对丙酸睾酮所致小鼠BPH具有显著的拮抗作用,其作用机制在一定程度上与降低小鼠血清T、E2含量有关。
Objective To study the antagonistic effect of Dangguibeimukushen Decoction （DBK） on benign prostatic hyperplasia （BPH） and its possiblemechanism. Methods Experimental prostatic hyperplasia was produced in the mice by testosterone injection.After 14 days of the treatments, the mice were sacrificed for measure-ment of the prostate glandular wet weight, the index of prostate gland （PI）, the pathologic changes of prostate gland by light microscopy and the contents of testosterone and estradiol in the serum. Results The prostate wet weight and PI decreased dose dependently after DBK treatment for 14 days compared with the BPH model group（P 〈0.05or P 〈0.01 ）. DBK reduced the serum testosterone, estradiol contents （P 〈0.05or P 〈0.01 ）. Conclusion DBK has significant antagonistic effect on BPH induced by testosterone propionate in mice, which may involve its regulatory action on the sex hormone balance.
出处
《中国药物警戒》
2010年第1期4-6,共3页
Chinese Journal of Pharmacovigilance
基金
中国中医科学院基本科研业务项目(ZZ2007012)
关键词
当归贝母苦参丸
良性前列腺增生
小鼠
Danggnibeimukushen pill
benign prostatic hyperplasia
mice
作者简介
陈野，男，在读博士研究生，病理学与病理生理学。
通讯作者：孙健，男，博士，药物化学分析。E-mail：sunjiankw@163．com
