摘要
目的调查临床分离病原菌的分布情况及常见病原菌的耐药现状,为临床合理用药提供依据。方法将2007年3月-2008年10月临床分离的3848株病原菌的分布及药敏试验结果采用WHONET5.3软件进行统计分析。结果3848株病原菌中革兰阳性菌857株（22.3%）,革兰阴性菌2270株（59.0%）,真菌721株（18.7%）;分离率居前3位的是白色假丝酵母菌、大肠埃希菌和鲍氏不动杆菌;耐甲氧西林金黄色葡萄球菌（MRSA）、耐甲氧西林表皮葡萄球菌（MRSE）和耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）的检出率分别为51.7%、80.7%和83.6%,未发现耐万古霉素葡萄球菌和肠球菌;产超广谱β-内酰胺酶（ESBLs）的大肠埃希菌、肺炎克雷伯菌和奇异变形菌的检出率分别是56.6%、28.3%和5.9%;各种肠杆菌科细菌对亚胺培南敏感,耐药率为0-1.3%,鲍氏不动杆菌和铜绿假单胞菌对亚胺培南的耐药率为38.3%和19.0%。结论真菌和非发酵菌的检出率增加,病原菌的耐药性增强,应引起临床的足够重视,并加强病原菌的耐药性监测。
OBJECTIVE To investigate the distribution of the clinical isolated pathogenic bacteria and the drug resistance of common bacteria so as to provide evidence for clinical rational use of drugs.METHODS The data of 3848 strains isolated from clinical specimens during from Mar 2007 to Oct 2008 and their sensitivity to antibiotics were statistically analyzed by WHONET 5.3.RESULTS Total of 3848 strains were identified including 857 Gram-positive strains（22.3%）,2270 Gram-negative strains（59.0%） and 721 fungal strains（18.7%）.The top three pathogens were Candida albicans,Escherichia coli and Acinetobacter baumannii.The detection rate of MRSA,MRSE,and MRCNS was 51.7%,80.7%,and 83.6%,respectively.There were no vancomycin-resistant staphylococci and enterococci detected.The detection rate of ESBLs producing strains in E.coli,K.pneumoniae,and Proteus mirabilis was 56.6%,28.3% and 5.9% respectively.All kinds of Enterobacteriaceae are sensitive to imipenem,resistance rate ranged from 0 to 1.3%.A.baumannii and Pseudomonas aeruginosa had higher resistance rate to imipenem（38.3% and 19.0%,respectively）.CONCLUSIONS The detection rate of fungi and non-fermentative bacteria increase and the resistance of the pathogens is increasing.We should pay more attention to the status,and enhance the resistance surveillance.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第23期3244-3246,共3页
Chinese Journal of Nosocomiology
关键词
病原菌
耐药性
抗菌药物
Pathogenic bacteria
Drug resistance
Antimicrobial agent
