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热休克蛋白70对离体大鼠供心的保护作用 被引量：1

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摘要 目前．心脏移植仍然是治疗终末期心脏病的有效方法．因此，对供心的保护一直受到临床的关注。热休克蛋白（HSP）是一组由热休克基因所编码合成的高度保守的、伴随细胞的蛋白，所有的细胞都能在应激情况下产生HSP，其能对抗严重的应激损伤。研究发现．在多种因素刺激下均可产生HSP。HSP70是HSP中最保守、最主要和含量最丰富的一类。
作者 池一凡 许慧 孙忠东 生伟 孙龙 侯文明
机构地区 青岛市市立医院 青岛大学医学院附属医院
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2009年第12期757-758,共2页 Chinese Journal of Organ Transplantation
关键词 热休克蛋白70 保护作用 离体大鼠 供心 HSP70 终末期心脏病 心脏移植 应激损伤
分类号 R363 [医药卫生—病理学]
作者简介 通信作者：孙忠东．E-mail：szd118@sina.com.
  • 相关文献

参考文献7

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  • 4Williamson CL,Dabkowski ER,Dillmann WH, et al. Mitochondria protection from hypoxia/reoxygenation injury with mitochondria heat shock protein 70 overexpression. Am J Physiol Heart Circ Physiol, 2008,294( 1 ) : H249-256.
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二级参考文献14

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共引文献123

同被引文献12

  • 1韩宏光,张仁福,汪曾炜,朱洪玉,王辉山,张南滨,宋恒昌.一体化综合性心肌保护对缺血再灌注损伤心肌超微结构改变的影响[J].中国临床康复,2004,8(18):3500-3501. 被引量：4
  • 2安立敏,胡健.热休克蛋白70与心肌缺血再灌注性损伤[J].中国心血管病研究,2005,3(7):540-542. 被引量：9
  • 3孙忠东,高尚志,毛志福,王志维,黄杰.热休克蛋白70表达对未成熟心肌保护作用的实验研究[J].中华胸心血管外科杂志,2005,21(6):356-358. 被引量：5
  • 4Madden LA, Sandstrom ME, Lovell RJ, et al. Inducible heat shock protein 70 and its role in preconditioning and exercise. Amino Acids,2008,34(4) :511-516.
  • 5Belke DD, Gloss B, Hollander JM, et al. In vivo gene delivery of HSP70i by adenovirus and adeno-associated virus preserves contractile function in mouse heartfollowing ischemia-reperfusion. Am J Physiol Heart Circ Physiol,2006,291 ( 6 ) : H2905-H2910.
  • 6Wei GZ, Zhou JJ, Wang B, et al. Diastolic Ca^2+ overload caused by Na^+/Ca^2+ exchanger during the first minutes of reperfusion results in continuedmyocardial stunning. Eur J Pharmacol,2007,572 ( 1 ) : 1-11.
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  • 8Stankiewiez AR, Lachapelle G, Foo CP, et al. Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. J Biol Chem,2005,280(46) :38729-38739.
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引证文献1

二级引证文献4

中华器官移植杂志
2009年 第12期

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