摘要
目的分析新生儿脐血胃促生长素（ghrelin）水平的影响因素，探讨胃促生长素在胎儿生长发育中的作用。方法采用放射免疫法测定100例新生儿脐血胃促生长素水平，分析其与胎龄、性别、分娩方式、出生体重、身长、头围和胎盘重量的关系。结果脐血胃促生长素浓度为606．2（488．4～914．4）pg／ml[中位数（P25～P75）]，不同性别、分娩方式间胃促生长素水平差异无统计学意义（P〉0．05）。不同胎龄、不同出生体重新生儿脐血胃促生长素水平差异有统计学意义（P〈0．05）。足月小于胎龄儿脐血胃促生长素水平[1211．7（668．8～1690．5）pg／ml]明显高于足月适于胎龄儿[750．4（534．2～1030．o）pg／ml]及大于胎龄儿[520．6（439．9～773．4）pg／ml]，差异有统计学意义（P〈0．05）。胎龄和出生体重是脐血胃促生长素水平的影响因素。结论脐血胃促生长素浓度可能随胎龄的增长而增加，其水平受出生体重的负反馈调节，可能是对胎儿宫内生长发育营养环境作出的适应性反应。
Objective To investigate the influencing factors of ghrelin concentration in cord blood and assess the role of ghrelin in fetal growth. Methods Plasma ghrelin concentrations were measured in cord blood of 100 neonates. The relationship between ghrelin and gestational age, gender, delivery mode, birth weight, body length, head circumference and placental weight were analyzed. Results The concentration of plasma ghrelin in cord blood of all 100 neonates was 606.2 （ 488.4- 914.4） pg/ml [median （P25-P65）]. There was no statistical difference between male and female infants or between neonates underwent cesarean section and vaginal delivery（P〉0.05）. Cord blood ghrelin levels were different in different gestational age and birth weight neonates （P 〈0.05）. Its concentrations were higher in term small for gestational age neonates [1211.7（668.8-1690.5） pg/ml] than in term average for gestational age newborns [750. 4（534. 2-1030. 0） pg/ml] and large for gestational age newborns [520. 6（439. 9-773. 4） pg/ml] （P〈0. 05）. Gestational age and birth weight were significant determinants of ghrelin concentrations（β0. 808,P=0. 000;β=-0. 469, P=0. 020）. Conclusions Cord ghrelin concentrations increases with advancing gestational age, but are down-regulated by fetal weight. Ghrelin may play a physiological role in fetal adaptation to intrauterine nutritional environment.
出处
《中华围产医学杂志》
CAS
2009年第6期418-420,共3页
Chinese Journal of Perinatal Medicine
基金
国家“十五”科技攻关计划项目（2004BA709809）
上海市医学重点学科资助项目
作者简介
现在上海交通大学附属国际和平妇幼保健院新生儿科
通信作者：蔡威，Email：caiw204@yahoo．com.cn
