摘要
目的探讨雷米普利对颈动脉易损斑块的影响及其预防脑梗死的临床疗效。方法将120例颈动脉粥样硬化斑块患者随机分成雷米普利治疗组与对照组,对照组服用阿司匹林100mg,1次/d;辛伐他汀20mg,1次/晚。治疗组在对照组的基础上加用雷米普利2.5mg,1次/d。疗程均为6个月,治疗前及治疗后应用彩色多普勒超声对所有患者的颈动脉狭窄程度、斑块性质进行评估;观察脑梗死发作情况。结果对照组60例患者中发生脑梗死17例(28.3%),治疗组60例患者中发生脑梗死6例(10.0%),治疗后两组脑梗死发生率间差异有统计学意义(P<0.05)。治疗前两组患者在颈动脉狭窄程度及斑块的超声病理分型方面的比较,差异均无统计学意义(P>0.05);治疗后治疗组颈动脉狭窄程度及不稳定性斑块所占比例明显降低,与对照组比较差异均有统计学意义(P<0.05)。结论雷米普利稳定颈动脉易损斑块预防脑梗死有明显疗效,且无明显的不良反应,安全性好。
Objective To explore the ramipril stabilizing carotid atherosclerosis plaques （CAP） in prevention of cerebral infarction （CI）. Methods 120 CAP patients were randomly divided into groups treatment （n = 60） and control （n = 60）. Control group received aspirin, 100 mg, once a day, and simvastatin, 20 mg/per night; treatment group received additional ramipril, 2. 5 mg, once a day, based on controls＇medication. Follow - up lasted 6 months. The carotid sclerostenosis degree, plaque nature were evaluated by color Doppler ultrasound before and after treatment, and CI onsets were observed. Resuits CI occurred in 17 in control group （28.3%）, and in 6 in treatment group （ 10. 0% ）, the difference was significant after treatment （ P 〈 0. 05 ）. No significant difference was noted in ultrasound pathological typing of carotid sclerostenosis degree and CAP between 2 groups before treatment （ P 〉 0. 05 ）. The proportion of carotid sclerostenosis degree, soft plaques, ulcer plaques reduced significantly in treatment group after therapy, significantly different from control （P 〈 0. 05 ）. Conclusion Ramipril stabilizing CAP effects obviously in prevention of CI, safe, without adverse reactions .
出处
《中国全科医学》
CAS
CSCD
北大核心
2009年第24期2210-2212,共3页
Chinese General Practice
关键词
雷米普利
动脉硬化
脑梗死
颈动脉疾病
Ramiprl
Arteriosclerosis
Cerebral infarction
Carotid artery diseases
