摘要
目的:分析藻酸双酯钠导致的阴茎异常勃起临床特点和发病机制。方法:分析我院收治的2例应用藻酸双酯钠后出现异常勃起患者临床表现、实验室检查及治疗。并检索文献,荟萃分析藻酸双酯钠导致的阴茎异常勃起的临床特点、治疗方法和发病机制。结果:CNKI《中国期刊全文数据库》1990年～2008年文献共报道12例静脉输注藻酸双酯钠后发生阴茎异常勃起,我院收治2例。14例均为缺血性阴茎异常勃起,我院的2例阴茎海绵体抽血检查DIC全项,D-Dimer分别为5320.73ng/mL、4752.45ng/mL。7例患者行海绵体抽血、灌洗并应用肾上腺素能药物有效,7例行阴茎头海绵体分流术。结论:静脉输注藻酸双酯钠可以导致缺血性阴茎异常勃起。输注藻酸双脂钠后患者阴茎海绵体局部血液高粘滞状态可能是其所致缺血性阴茎异常勃起的发生机制。保守治疗往往无效,应尽早行海绵体抽血、灌洗或阴茎头海绵体分流手术。
Objectives： To investigate the clinical feature and mechanism of priapism induced by intravenous Polysaccharide sulfate. Methods： Two patients with priapism induced by Polysaccharide sulfate in our hospital were enrolled in this study. We analyzed the clinical manifestation, laboratory examination and treatment of two patients. We also reviewed the cases reported in publish literature , analyzed the clinical manifestation ,clinical treatment and pathogenesis of priapism induced by Polysaccharide sulfate. Result： There were 14 patients with ischemic priapism induced by intravenous Polysaccharide sulfate include 12 cases reported in publish in CNKI and 2 cases we had treated. The D - dimer value of DIC of aspirated intracavernosal blood from two patients we had treated rised obviously. The penis were soft of 7 patients by aspiration of the excess blood from the penis , irrigation by saline solution with heparin, injection of a - adrenergic agonists. The Corporospongiosus shunt was constructed in the other 7 patients. Conclusions： The present study suggested that intravenous Polysaccharide sulfate can induce priapism. The blood hyperviscous of the corpus cavernosum induced by intravenous Polysaccharide sulfate may be the pathogenesis of priapism. Conservative treatment is insufficient. The aspiration of intracavernosal blood and surgery were necessary to achieve detumescence.
出处
《中国性科学》
2009年第11期9-11,共3页
Chinese Journal of Human Sexuality
作者简介
李清（1970-），男，山东枣庄人，医学博士，主治医师，主要从事泌尿外科临床研究。
