摘要
采用免疫组织化学法染色,标记基底膜的特异性成分Ⅳ型胶原、层粘连蛋白对宫颈鳞状上皮不典型增生、原位癌,早浸癌及浸润癌的基底膜变化进行观察研究。结果显示正常及不典型增生情况下基底膜是完整,连续的。原位癌基底膜通常是连续的,偶有中断。早浸癌基底膜通常是断续的,偶尔癌巢周围可出现完整、连续的基底膜。浸润癌基底膜的表现与细胞分化有关,分化好的癌巢周围存在基底膜,分化差的则缺少基底膜。基底膜变化的机理可能在于合成和分解代谢的不平衡。
The basement membrane(BM) of Uterine cervical atypical hyperplasia(AH), Carcinoma in situ(CIS), microinvasive carcinoma (MICA) and invasive squamous cell carcinoma (IC) were studied by immunoperoxidase-anti-peroxidase (PAP)technique using antibodies to type Ⅳ collagen and laminin. Results showed that the presence and distribution of basement membrane material (Type Ⅳ collagen and Laminin) in AH/CIS were usually continuous. On the contrary the irregular discontinuity was found in MICA and IC. BM were present in well differentiated carcinoma. These observations suggested that BM deposition and the degree of differentiation of the uterine cervical squmous cell carcinoma should be correlated.BM defects may be caused by an imbalance between degradation and synthesis.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1990年第4期234-236,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
宫颈鳞癌
IV型胶原
层粘连蛋白
Type Ⅳ collagen
laminin
basement membrane: cervical squmous cell carcinoma
