摘要
目的:探讨病毒性肝炎患者血液流变学及部分血脂指标的异常变化。方法:189例病毒性肝炎患者分为急性肝炎组、轻度慢性肝炎组、中度慢性肝炎组、重度慢性肝炎组、肝硬化组、重症肝炎组。采用血液流变技术测定全血粘度(ηb)、血浆粘度(ηp)、红细胞压积(Hct)、血沉(ESR)、血沉方程K值(Kesr)、红细胞聚集指数(RE)、红细胞电泳指数(EE);采用罗氏MODULAR全自动生化分析仪测定甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),并与55例健康人群对照分析。结果:各肝病组ηb、ηp、RE、EE均高于对照组(P<0.01,肝硬化组和重症肝炎组ηp除外),Hct、Kesr低于对照组(P<0.01),ESR和Kesr在肝硬化组和重症肝炎组有显著性差异(P<0.05)。肝硬化组、重症肝炎组TG、TC、HDL-C、LDL-C水平与对照组比较均显著下降(P<0.01),ηb、ESR、Kesr、RE、TC、LDL-C与急性肝炎组和不同程度慢性肝炎组间比较均有显著性差异(p<0.05);重症肝炎组TC与肝硬化组比较有显著性差异(P<0.01);急性肝炎组与不同程度慢性肝炎组比较,Hct、RE、EE、TG、HDL-C、LDL-C具有显著性差异(P<0.01);重度慢性肝炎组ηb、RE、EE、TC、HDL-C、LDL-C与轻、中度慢性肝炎组间均有显著性差异(P<0.01)。结论:病毒性肝炎患者存在不同程度的血流变指标和血脂异常变化,分析其变化规律对临床诊断及治疗有重要意义。
Objective:To analysis the abnormal change of lipid and blood rheology in the patients with viral hepatitis. Method: Choosed 189 patients with virus hepatitis who were divided into acute group,chronic lightly degree group,chronic midrange degree group,chronic heavily degree group,hepatic cirrhosis group,heavy group and compared with 55 healthy subjects. ηp,ηb,HCT,ESR,RE and EE were tested by blood rheology test equipment. TG,HDL-C ,LDL-C and TC were studied with biochemistry analysis equipment.Results: The datas of ηp,RE and EE in control group were lower than experiment groups.(acute,chronic lightly degree,chronic midrange degree,chronic heavily degree,P<0.01).Compared with control,the value of ηb was higher in hepatic cirrhosis and heavy group. HCT was higher than experiment groups(P<0.01).TG,TC,HDL-C,LDL-C,ηp,ηb,HCT,ESR,RE and EE in hepatic cirrhosis group and heavy group had obvious difference from acute and chronic group.TC had significant difference between hepatic cirrhosis group and heavy group(P<0.01). Acute group compared with chronic group,TG,TC,HDL-C,LDL-Cηp,ηb,HCT,RE and EE had obvious changes except ESR.Conclusion: The index of lipid and blood rheology had abnormal change in the patients with viral hepatitis,it had important significance to clinical diagnosis and treatment by analyzing the rule of changes.
出处
《微循环学杂志》
2009年第4期44-45,共2页
Chinese Journal of Microcirculation
作者简介
刘洁（1968～），女。汉族。副主任技师
