摘要
目的比较西酞普兰与马普替林治疗老年抑郁症的疗效及安全性。方法将96例老年抑郁症住院患者随机分为两组,48例应用西酞普兰治疗,48例应用马普替林治疗,疗程均为8周。采用汉密尔顿抑郁量表(HAMD)、临床疗效总评定量表(CGI-SI)评定临床疗效,治疗中出现的不良反应量表(TESS)评定药物不良反应。结果西酞普兰与马普替林治疗老年抑郁症的疗效相当(P>0.05),但前者不良反应少(P<0.05)。结论西酞普兰治疗老年抑郁症疗效显著,不良反应少,安全性高。
Objective To compare the efficaey of citalopram and maprotiline on the quality of life in senile depression patients. Methods 96 patients with senile depression were assigned randomly to citalopram group or maprotiline group for 8 weeks. Clinical curative effects were assessed with the Hamilton Depression Scale（HAMD） and Clinical Global Impression（CGI）. Side effects were assessed with the Treatment Emergent Symptom Scale（TESS）. Results The efficacy of citalopram was similar to that of maprotiline （ P 〉 0. 05 ） , but citalopram had fewer side effects （ P 〈 0. 05 ）. Conclusion Citatopram has significant curative efficacy,milder adverse reactions and higher safety in the treatment of elderly depressive.
出处
《四川精神卫生》
2009年第4期218-220,共3页
Sichuan Mental Health
