摘要
随着火灾事故增多,火灾烟气吸入导致的一氧化碳和氢氰酸复合中毒已成为氰化物中毒的首要途径。羟钴胺静脉注射给药可用于已知或疑似氰化物中毒的解毒治疗。其进入体内后可与氰离子直接络合而不需要血红蛋白参与,因而不降低机体携氧能力,非常适于火灾现场烟气吸入患者的院前救治。本文对羟钴胺的作用机制、生物活性、药代动力学、安全性及临床疗效进行综述。
With an increase in fire accidents, smoke inhalation of carbon monoxide and hydrocyanic acid has become the main reason of cyanide poisoning nowadays. Hydroxocobalamin is an intravenous antidote of known and suspected cyanide poisoning, which has the unique action mechanism of direct tightly binding cyanide ions. It does not need the participation of hemoglobin during the detoxification process, and thereby does not lower the oxygen-carrying capacity of victim＇s blood. Therefore, hydroxocobalamin is quite suitable for pre-hospital use among smoke inhalation victims in fire. Recent progress in mechanism, bioactivities, pharmacokinetics, safety and clinical efficacy of hydroxocobalamin is briefly reviewed in this paper.
出处
《国际药学研究杂志》
CAS
2009年第5期370-372,共3页
Journal of International Pharmaceutical Research
关键词
解毒药
羟钴胺
氰化物中毒
antitode
hydroxocobalamin
cyanide poisoning
作者简介
杨美燕，女，助理研究员，研究方向：药物新剂型与新技术，Tel：01046931638，E-mail：ymyzi@163．com
通讯作者：高春生，男，副研究员，研究方向：新型药物传递系统，Tel：01046931638，E-mail：largedna@163．com
