摘要
目的探讨不同类型脑膜炎患者的脑脊液乳酸(LA)、蛋白含量和酶活性变化的临床意义。方法应用全自动生化分析仪检测98例脑膜炎患者(化脓性脑膜炎、结核性脑膜炎、病毒性脑膜炎)和25例无神经系统疾病、肿瘤、免疫性疾病、血液系统疾病及炎症而需要外科手术的腰麻(对照组)的脑脊液LA、总蛋白、CRP含量和酶(LDH、ADA、AST)活性,并进行统计学分析。结果对照组脑脊液总蛋白、AST明显低于化脓性脑膜炎组(化脑组)、结核性脑膜炎组(结脑组)、病毒性脑膜炎组(病脑组)(P<0.01),对照组脑脊液LA、CRP、LDH、ADA明显低于化脑组、结脑组(P<0.01),低于病脑组,但差异无统计学意义;化脑组脑脊液LA、CRP、总蛋白、LDH、AST明显高于结脑组、病脑组(P<0.01);结脑组脑脊液LA、CRP、总蛋白、LDH、AST明显高于病脑组(P<0.01);结脑组脑脊液ADA明显高于化脑组、病脑组(P<0.01),化脑组高于病脑组,但差异无统计学意义。结论脑脊液LA、蛋白含量和酶活性变化对不同类型脑膜炎的诊断、治疗以及预后观察有重要的临床意义。
Objective To investigate the clinical value of the changes of cerebrospinal fluid（CSF） Lactic acid （LA）, protein and enzyme activity in meningitis. Methods LA,total protein（TP） and enzyme activity （LDH, ADA,AST） in the CSF were detected in 98 patients with meningitis and 25 normal control suhjects（NC）. Results Compared with NC group,there were significantly elevated CSF-TP and CSF-AST level in purulent meningitis（PM）,T tuberculous meningilis（TM） and Viral meningitis（VM） （P〈0. 01 ）. The NC group had remarkably lower CSF-LA,CSF-CRP,CSF-LDH and CSF-ADA level than PM and TM （P〈0.01）. The PM group had remarkably higher CSF-LA, CSF-CRP, CSF-TP, CSF-LDH and CSF-AST level than TM and VM （P〈0.01）. Compared with VM group, the TM group had remarkably higher CSF-LA, CSF-CRP, CSF-TP, CSF-LDH, and CSF AST level （ P〈0.01 ）. In TM group,CSF-ADA level was significantly higher than in TM and VM group（P〈0.01）. Conclusion The changes of cerebrospinal fluid LA,prolein and enzyme activity have an important role in the diagnosis and prognosis of meningitis.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第19期2439-2440,共2页
Chongqing medicine
关键词
脑脊液
乳酸
蛋白质
酶活性
脑膜炎
cerebrospinal fluid
lactic
acid
protein
enzyme activity
meningitis
