摘要
目的:探讨乳腺浸润性导管癌的钼靶X线征象与激素受体ER、PR和癌基因C-erbB-2之间的相关性。方法:回顾性分析68例经乳腺钼靶X线摄影、手术及病理证实的乳腺浸润性导管癌的X线表现。术后标本应用免疫组织化学染色测定乳腺癌原发灶癌细胞ER、PR和C-erbB-2表达情况,并分析其与钼靶X线征象之间的关系。结果:68例乳腺浸润性导管癌中,肿块54例,占79.4%,出现毛刺征31例,占45.6%,有钙化者27例,占39.4%,结构紊乱和密度增高者6例,占8.8%。乳腺癌X线征象钙化与癌细胞ER及PR阳性表达之间呈负相关性(P<0.05);C-erbB-2阳性表达水平与钙化的癌细胞之间呈正相关性(P<0.05)。结论:乳腺癌钼靶X表现与激素受体ER、PR及癌基因C-erbB-2之间存在一定的相关性。通过乳腺癌的钼靶X线表现可以预测ER、PR及C-erbB-2的表达,从一定程度上反映了癌细胞的生物学行为和预后,为临床内分泌治疗方案的选择提供客观依据。
Objective：To study the correlation of mammographic signs to the expressions of ER,PR（estrogen/progesterone recepter）and C-erbB-2 in infiltrating ductal carcinoma of breast （IDC）. Methods：Pre-operative mammography was performed in all the 68 cases of patients with pathologically-proved IDC Of breast. The specimens of mastectomy of the IDC were stained with immunohistochemistry, and the expression of ER, PR, and C-erbB-2 were measured. Results： On the mammograms of the 68 cases, masses were shown in 54 cases （79.4%）, spicule sign in 31 cases （45.6%）, calcifications in 27 cases （39.4%） and breast architecture distortion only in 6 cases （8.8%）. The positive expression of ER,PR and C-erbB-2 were found in 41cases （60.3%）,45 cases （66.2%）and 39 cases （57.4%） respectively. ER and PR positive expression was negatively correlated with the calcification of infiltrating duct carcinoma of breast （P 〈 0.05）, but C-erbB-2 positive expression was positively correlated with the calcification of infiltrating duct carcinoma of breast （P 〈 0.05）. Conclusion： The molybdenum target mammographic features of IDC were closely correlated to the expressions of ER, PR and C-erbB-2,and these features were in a considerable extent reflecting the biological behaviors of tumor cells and prognosis of cases. Therefore, molybdenum target mammographic features were helpful in treatment planning of breast cancer.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第9期1262-1264,共3页
Journal of Nanjing Medical University(Natural Sciences)
