摘要
目的探讨血清胱抑素C(Cys C)水平检测对评估肝硬化患者肾小球功能损害的价值及与肝硬化程度的关系。方法60例肝硬化患者按照Child-Pugh分级并测定血清Cys C、血肌酐(Scr)。结果60例肝硬化患者中,Cyst C浓度异常27例(45%),Scr异常5例(8.3%),差异有显著性意义(P<0.05)。肝硬化患者Cys C浓度及异常程度均随Child-Pugh分级的增加而增高;Cys C与Child-Pugh分级相关性的密切程度高于Scr与Child-Pugh分级的相关性。结论肝硬化患者通过Cyst C的检测能够灵敏反映肾小球功能的变化,优于Scr的检测,与肝硬化程度密切相关。
Objective To investigate the practical value of serum cystatin C （ Cys C ） for the evaluation of renal function in patients with cirrhosis. Methods Sixty patients with cirrhosis calssfied by Child-Pugh scores were examined with serum cystatin C and serum creatinine （Scr） concentration. Results There were 27 abnormal Results using serum cystatin C tests, while only 5 cases using serum ereatinine tests（ P 〈 0. 05 ）. The level of Cys C were increased in patients with grade B and C while serum creatinine were nearly normal with grade A. The correlation coefficient between level of Cys C and Child-Pugh score was 0. 81 ,which was larger than that between the level of creatinine and Child-Pugh seore（ P 〈 0. 05） . Conclusions The test of serum Cys C is an ideal marker to evaluate renal funtion in cirrhotic patients, and has very close relationship with Child-pugh score.
出处
《实用医院临床杂志》
2009年第4期67-68,共2页
Practical Journal of Clinical Medicine
关键词
胱抑素C
肝硬化
肌酐
Cystatin C
Cirrhosis
Creatinine
