摘要
目的观察冠心病稳定型心绞痛患者及高危因素患者和健康人血浆可溶性OX40配体(sOX40L)和白细胞介素10(IL-10)水平及两者之间的相关性,探讨sOX40L在冠心病中的作用及其相关因素。方法采用酶联免疫吸附法测定35例稳定型心绞痛患者、30例高危因素患者以及20名健康人血浆中sOX40L及IL-10的水平。结果稳定型心绞痛患者血浆OX40L水平[(24.95±15.60)ng/L]高于健康对照组[(16.44±11.31)ng/L],差异有统计学意义(P<0.05),略高于高危因素组[(19.99±9.35)ng/L],但差异无统计学意义(P>0.05)。与健康对照组相比,稳定型心绞痛组IL-10水平显著降低[(27.3±9.9)ng/L比(20.5±8.9)ng/L,P<0.05]。血浆sOX40L与IL-10呈显著负相关(r=-0.394,P=0.000)。结论本研究首次观察到血浆可溶性OX40L水平与抗炎细胞因子IL-10的水平呈显著负相关,提示sOX40L可能通过影响IL-10的水平而影响冠心病的危险程度。
Objective To investigate the relationship between plasma soIuble OX40L（sOX40L） and Interleukin- 10 （IL-10） levels in patients with stable coronary heart disease. Methods Plasma sOX40L and IL-10 levels were determined by enzyme-linked immunosorbent assay in 35 patients with stable angina pectoris, 30 individuals with risk factors of coronary heart disease and 20 healthy controls. Results The sOX40L level was significantly higher in patients with stable angina than in healthy control group [ （ 24. 95 ± 15.60 ） ng/L vs. （ 16.44 ± 11.31 ） ng/L, P 〈 0. 05 ] . Compared with control group, the level of plasma IL-10 significantly decreased in stable angina group [ （27. 3 ± 9. 9）ng/L vs. （ 20. 5 ± 8.9 ） ng/L, P 〈 0. 05 ]. Blood sOX40L level were negatively correlated with IL-10 （ r = - 0. 394, P = 0. 000）. Conclusions Plasma sOX40L level was negatively correlated with IL-10. OX40L may increase the risk of CHD by inhibiting IL-10 secretion.
出处
《中国心血管杂志》
2009年第4期278-281,共4页
Chinese Journal of Cardiovascular Medicine
作者简介
通讯作者：彭道泉，电子信箱：pengdq@hotmail．com
