摘要
目的观察胸腺肽α1(Tα1)对颅内感染病人炎症因子及免疫功能的影响,探讨Tα1在颅内感染治疗中的作用。方法将2006年2月～2008年6月间收治的52例颅内感染病人,随机分为用药组(27例)和对照组(25例),在控制感染的基础上用药组加用Tα1,并观察细胞因子水平的变化以及T细胞亚群CD3+、CD4+、CD8+、NK细胞百分率的变化。结果两组病人肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)水平均呈升高趋势,但对照组趋势更加明显,治疗第4天用药组的CD3+、CD4+较用药前升高,明显高于对照组。结论Tα1可以调节严重感染病人肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)等细胞因子的水平,减轻炎症反应,改善病人的免疫功能。
[Objective] To investigate the effect of thymosin-α1 on immune function and cytokines in the CNS infective and discuss the therapeutic function of thymosin-α in sepsis. [Methods] Fifty-two sepsis patients admitted between February 2006 and June 2008 were randomly divided into the treatment group （27 cases） and control group （25 cases）. Thymosin-al was used in the treatment group on the basis of infection control treatment. The concentration of cytokines （TNF-α, IL-6） and the percentage of CD3＋, CD4＋, CD8＋, NK cell were observed. [Results] The concentrations of TNF-α and IL-6 were increased significantly in both group. But it was more prominently in the control group. The percent of CD3＋, CD,4＋ cell increased more significantly in thymosin-α1 treatment group than in the control group. [Conclusion] Thymosin-α can modulate the release of TNF-α, IL-6, mitigate the inflammatory reaction and improve the immune function.
出处
《中国医学工程》
2009年第2期88-90,共3页
China Medical Engineering
