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非甾体抗炎药胃肠道不良反应的预防 被引量：15

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摘要 非甾体抗炎药（NSAIDs）是目前临床治疗类风湿性关节炎和骨关节炎的主要治疗药，也是最重要的解热镇痛药，根据NSAID对环氧化酶（COX）的抑制情况分为环氧化酶-1（COX-1）抑制药和COX-2抑制药。COX-1抑制药主要不良反应常见的有胃肠道反应，如食欲不振、溃疡、出血，甚至穿孔。COX-2抑制药的疗效优于或等同于COX-1抑制药，而胃肠道耐受性有所改善。但此类药物出现了一些新的严重的不良反应如心脑血管损害及肾功能损害等。近来FDA报告，此类药物可能出现严重的心血管系统不良反应，要求在该类药物的说明书上黑框标明对心血管系统的不良反应，以期引起医生和病人的重视。
作者 刘亚州 宋铁兵 刘瑞鹏 徐晓弘
机构地区 黑龙江康麦斯药业有限公司 大庆油田总医院
出处 《中国药师》 CAS 2009年第8期1149-1150,共2页 China Pharmacist
关键词 非甾体抗炎药 不良反应 预防
分类号 R971.11 [医药卫生—药品]
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参考文献10

  • 1张骏艳,李俊,金涌.非甾体抗炎药的临床研究新进展[J].安徽医药,2005,9(2):81-84. 被引量：10
  • 2Schnitzer TJ, Kong SX, Mavros PP, et al. Use of nonsteroidal antiinflammatory drugs and gastroprotective agents before the advent of cyclooxygenase-2-selective inhibitors: analysis of a large United States claims database [J ]. Clin Ther, 2001,23 (12) : 1984-1998.
  • 3Hooper L, Brown TJ, Elliott R,et al. The effectiveness of five strategies for the preveotion of gastroinlestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematicreview [ J ]. BMJ, 2004,23 (329) :948-960.
  • 4Pilotto A, Franceschi M, Leandro G, et al. The risk of upper gastrointestinal bleeding in elderly users of aspirin and other non-steroidal anti-inflammatory drugs: the role of gastroproteetive drugs [ J]. Aging Clin Exp Res, 2003,15 ( 6 ) :494 -499.
  • 5Ashworth NL, Peloso PM, Muhajarine N, et al. Risk of hospitalization with peptic ulcer disease or gastrointestinal hemorrhage associated with nabumetone, Arthrotec, diclofenac, and naproxen in a population based cohort study [ J]. J Rheomalol, 2005,32 ( 11 ) :2212-2217.
  • 6Koch M, Dezi A, Tarquini M,et al. Prevention of non-steroidal antiinflammatory drug-induced gastrointestinal mueosal injury: risk factors for serious complications[J]. Dig Live Dis, 2000,32(2) :138-151.
  • 7Munger MA, Gardner SF, Ateshkadi A, et al. Misoprostol effects on diclofenac-induced cardiorenal changes in salt-sensitive patients with hypertension : the MEDIC Study [ J ]. Pharmacotherapy, 2008,28 (7) : 834 -842.
  • 8KonczTA, ListerSP, MakinsonGT. Gastroprotection in patients prescribed non-selective NSAIDs, and the risk of related hospitalization [J]. Cur Med Res Opin, 2008,24(12) :3405-3412.
  • 9van Soest EM, Sturkenboom MC, Dieleman JP, et al. Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage [ J]. Aliment Pharmacol Ther, 2007, 26 ( 2 ) : 265 -275.
  • 10Cote GA, Norvell JP, Rice JP, et al. Use of gastroprotection in patients discharged from hospital on nonsteroidal anti-inflammatory drugs [J]. Am J Ther , 2008,15(5)444-449.

二级参考文献27

  • 1Dequeker J,Hawkey C,Kahan A,et al. Improvement in gastrointestinal tolerability of the selective cyclooxygenase ( COX ) -2 inhibitor meloxican compared with piroxicam:results of the safety and efficacy largescale evaluation of COX-inhibiting therapies (SELECT) trial in Osteoarthritis [ J ]. Br J Rheumatol, 1998, ( 37 ) :946.
  • 2Lund B, Distel M, Bluhmki E. A double-blind randomized placebo controlled study of efficacy and tolerance of meloxican treatment of patients with osteoarthritis of the knee [ J]. Scand J Rheumatol,1998,27:32.
  • 3齐若梅,王振纲,王树歧.一氧化氮的研究进展[M].2003药理学进展,74-7.
  • 4Vane J.The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action[J].Drugs,1987,33(supple 1):18-27.
  • 5Halliday G,Robinson SR,Shepherd C,et al.Alzheimer,s disease and inflammation:a review of cellular and therapeutic mechanisms [J].Clin Exp Pharmacolo Physiol,2000,27:1-8.
  • 6Blain H,Jouzeau JY,Blain A,et al.Nonsteroidal anti-innammatory drugs with selectivity for cyclooxygenasa-2 in Alzherimer disease: Rationable and perspectives [ J ]. Press Med ( French ) ,2000,29: 267.
  • 7Rich JB, Rasmusson DX, Folstein, MF, et al. Neurology, 1995,45(1):51 -5.
  • 8Kniss DA. Cyclooxygenase in reproductive medicines and biology [J]. J Soc Gynecol Investig, 1999,6(16) :285 -92.
  • 9Xian-Zhang Ding, Rene Henning, Tomas E. Adrian. Lipoxygenase and cyclooxygenase metabolism:new insights in treatment and chemoprevention of pancreatic cancer[J]. Molecular Cancer, 2003,2(1) :10.
  • 10Kirsten B ,Moysich, Ravi J. Menezes, Adrienne ronsani. Regular aspirin use and lung cancer risk[J]. BMC Cancer, 2002,2( 1 ) :31.

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同被引文献77

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二级引证文献76

中国药师
2009年 第8期

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