摘要
目的 观察比较伊布利特与普罗帕酮转复心房颤动和心房扑动的疗效。方法按照制定的入选标准及排除标准选择受试者，采用随机单盲对照进行观察。46例房颤／房扑患者，随机分入2组，伊布利特组（n=24）、普罗帕酮组（n=22）。伊布利特1mg于10min内静注，普罗帕酮70mg于10min内静注，然后观察10min，若房扑或房颤仍未终止且QTc间期〈600ms，分别给予第2剂，剂量相同。结果观察房扑或房颤转复所用时间，并观察房扑或房颤于用药后0～90min、90min～4h两组转复率，通过对比分析，两组在2个时间段内的转复率及转复时间比较差异有统计学意义（P〈0．01）。结论伊布利特是使房扑、房颤快速转律的最有效药物，尤其是在用药后0～90min的时段内心房颤动和心房朴动的转复疗效更佳，明显优于普罗帕酮。
Objective To compare the ibutilide and propafenone in the conversion of atrial fibrillation and atrial flutter effect. Methods In accordance with the eligibility criteria and eliminative criteria, randomized, single - blind controlled observation ,46 cases of atrial fibrillation or atrial flutter were divided into two groups. The ibutilide group included 24 patients,the propafenone included 22 patients. Ibutilide 1mg within one injection pump, propafenone administrate at one time injection pump within 10 minutes ,and then observed 10 minutes ,if the atrial fibrillation or atrial flutter terminated ,and the QTc 〈 600 ms, second dose were given. Results Observing the time of conversion of atrial fibrillation or atrial flutter in the two groups, and observing the rate of conversion in 0 -90 rain and 90 min -4 h time. By contrasting the two groups in two periods and the difference was statistically significant （ P 〈 0. 01 ）. Conclusions Ibutilid is rapid and most effective drug of conversion atrial fibrillation or atrial flutter, particularly in 0 - 90 min after administration. In the period conversion atrial fibrillation and atrial flutter better efficacy, brtter than propafenone.
出处
《中国实用医刊》
2009年第14期22-23,共2页
Chinese Journal of Practical Medicine
关键词
伊布利特
普罗帕酮
心房颤动
心房扑动
药物转复
Ibutilide
Propafenone
Atrial fibrillation
Atrial flutter
Drug conversion
