摘要
研究发现,在中枢神经系统及外周神经系统中,免疫细胞和分子在神经病理性疼痛过程中发挥着越来越重要的作用,对传统的以神经元为中心的疼痛理论发起了挑战。神经损伤后外周的肥大细胞、中性粒细胞、巨噬细胞和T淋巴细胞等免疫细胞所产生的级联炎性反应以及胶质细胞的激活是神经病理性疼痛形成和维持的关键因素,这些免疫细胞通过释放大量炎性介质最终导致疼痛的产生。
It has been shown that immune cells and molecules both in the periphery and the central nervous system play a more and more important role in neuropathic pain, These findings posed a big challenge to the conventional concepts of pain in which neurons were usually thought as the major player. Inflammation reaction involved a cascade of different immune cell types（such as mast cells, neutrophils, macrophages and T lymphocytes） and the the activation of glia cells after nerve damage in the nervous system are crucial for the development and persistence of neuropathic pain. In addition, immune cells and glia release numerous compounds that contribute to pain. In this review we discussed the different immune cell types that contribute to neuropathic pain and the possible underlying mechanisms.
出处
《国际病理科学与临床杂志》
CAS
2009年第3期267-271,共5页
Journal of International Pathology and Clinical Medicine
作者简介
董良，博士研究生，主要从事疼痛与临床麻醉的研究。
通讯作者：郭曲练，E-mail：quliangguo@hontmail.com
