摘要
目的调查志贺菌在浙江省温州地区流行的主要血清型和耐药性。方法收集临床分离的志贺菌株进行生化鉴定、血清学分型和抗生素敏感性试验。结果116株志贺菌中28株为宋内志贺菌,占24.1%;80株为福氏志贺菌,占68.9%(包括4株福氏变异株,占总数的3.5%),痢疾志贺菌7株占6.0%,鲍氏志贺菌1株占0.9%。宋内志贺菌对抗菌药物的敏感率依次为氟喹诺酮类(萘啶酸为14.4%)100%、第三、四代头孢为92.9%,对复方新诺明、萘啶酸、氨苄西林呈高耐药性。福氏志贺菌对诺氟沙星、环丙沙星、莫西沙星、洛美沙星、左氟沙星的敏感率为80%左右;对三、四代头孢的敏感率为97%,但头孢噻肟的敏感率仅为22.3%。鲍氏志贺菌出现严重耐药,只有亚胺培南和美洛匹宁敏感,其他均耐药。结论温州地区志贺菌感染以福氏志贺菌和宋内志贺菌为主,福氏志贺菌中以福氏4 c型为主,其次为血清2 a型和2b型。福氏志贺菌对各种抗生素耐药性有增高趋势;并出现严重耐药菌株,必须引起临床重视。
Objective To investigate the scrotype and drug resistance of Shigella circulated in Wenzhou. Methods Biochemical identification, serotyping and drug susceptibility test were conducted for the clinical isolates of Shigella strains. Results Among 116 strains of Shigella isolated, 28 strains were Shigella sormei （24.1%）, 80 strains were Shigella flexneri （68.9%）, including 4 straims of variant of Shigellaflexneri （3.5%）, 7 swains were Shigella dysenteriae（ 6. 0% ）, 1 strain was Shigella boydii （O. 9% ）. Shigella sonnei was sensitive to following antibiotics： fluoroquinolones （100%） and cephaloglycine and cephalexin （92.9%）, but was highly resistant to cotrimoxazole, nalidixic acid and ampiciUin. For Shigella flexneri, the sensitive rates to norfloxacin, ciprofloxacin, moxifloxacin, lomefloxacin and levofloxacin were about 80%, the sensitive rates to cephaloglycine and cephalexin were 97%, but the sensitive rate to cefotamine was only 22.3%. Shigella boydii was highly drug resistant, which was only sensitive to imipenem and meropenem. Conclusion The predominate strains to cause Shigella infection in Wenzhou were Shigella flexneri and Shigella sonnei, of Shigella flexneri, serotype 4c was predominated, followed by 2a and 2b. The resistant rates of Shigella flexneri to all antibiotics were on the increase and the drug resistant strain had emerged, which should be pay more attention to.
出处
《疾病监测》
CAS
2009年第5期334-336,共3页
Disease Surveillance
关键词
志贺菌
血清分型
耐药性
Shigella
serotyping
drug resistance
作者简介
沈丽珍，女，浙江省人，主要从事微生物检验工作 通信作者：沈丽珍，Tel：0577—88913784，Email：shenlizhen01@163．com
