摘要
疾病是影响畜牧业生产的主要因素,虽然传统的疾病控制方法对疾病的预防和治疗起到了重要作用,但随着分子生物学和基因工程技术的发展,分析在抗性和易感群体中候选基因的标记等位基因频率差异,结合遗传育种技术,提高家畜的抗病性与健康水平已成为当今提高家畜生产水平的重要途径。甘露糖结合凝集素(mannan-binding lectins,MBL)是构成人和动物血清补体凝集素途径的主要成分,在先天免疫过程中起重要作用。笔者简述了MBL的分布、结构、功能,介绍了MBL基因与抗病力的关系,对其作为家畜抗病育种遗传标记的应用前景进行了展望。期望MBL作为遗传标记,通过标记辅助选择进行抗病育种可以培育出抗病力强的家畜品种。
Disease is the major factor that affects livestock production. Although the traditional methods of disease control played an important role in disease prevention and treatment, as the development of molecular biology and genetic engineering technology, to improve the disease resistance and health of livestock has become an important way to increase the production level through genetics and breeding technology together with analyzing the marker allele frequency differences of the candidate gene in resistance and susceptibility groups. Mannan-binding lectin （MBL） is the main ingredient to constitute human and ani- mal serum complement lectin and plays an important role in the innate immune. This article outlines the distribution, structure and functions features of MBL, introduces the relationship between the MBL gene and diseases resistance, and prospects the potential application that MBL is used as genetic marker for livestock breeding for disease resistance. MBL is expected as a ge- netic marker that can produce high disease-resistant livestock varieties by marker-assisted selection to carry out the breeding for disease resistance.
出处
《中国畜牧兽医》
CAS
北大核心
2009年第6期45-49,共5页
China Animal Husbandry & Veterinary Medicine
基金
科技部"863"项目(2006AA10Z1D9)
山东省良种工程高分子育种项目(2007LZ015-06)
山东省农业科学院高技术育种项目(2007YCX019)
关键词
甘露糖结合凝集素
生物学功能
多态性
抗病育种
mannan-binding lectin （MBL）
biological function
polymorphism
disease resistance breeding
作者简介
作者简介：刘梅（1982-），女，山东人，硕士，研究方向：细胞生物学。
通信作者：王长法（1967-），男，博士，研究方向：遗传育种。E—mail：wcf1967@yahoo．com．cn
