摘要
尝试了多种从金银花中提取绿原酸的工艺流程,但结果都不能令人满意。从实验中总结了许多关于绿原酸的性质,从而设想用乙醇和水组成的混合溶剂作提取剂,用盐酸作电离抑制剂,水浴加热回流。并利用绿原酸在热乙醇和冷乙醇中溶解度相差非常大的特点,使其在热乙醇中溶解而在冷乙醇中析出,从而达到分离的目的。并研究了实验中乙醇浓度、溶剂用量、水浴温度、回流时间以及pH值对提取绿原酸的影响,用正交设计选取了最佳工艺。结果表明,最佳提取条件为:40%乙醇(体积分数)、溶剂用量为12倍、水浴温度80℃、回流时间2.5h、pH值6。
Some usual methods have been attempted to extract chlorogenic acid from flos lonicerae, but satisfactory results cannot be achieved. After studied on a lot of characters of flos lonieerae and ehlorogenic acid from the experiment, it was designed to use alcohol -water mixture as extractant and hydrochloric acid to prevent ionization interference, extract chlorogenic acid from flos lonicerae with back flow in water -bath. Using the greatly different solubility of ehlorogenic acid in hot and cold alcohol, chlorogenic acid was dissolved in hot alcohol and precipitated in cold alcohol. In the experiment, the effect of alcohol concentration, solvents volume, temperature of water - bath, reflux time and pH value of solution were studied. Using orthogonal design, the optimum conditions were chosen. The optimum conditions are： alcohol concentration, 40%; solvents volume, 12 fold; temperature of water bath, 80℃ ; reflux time, 2.5h; pH value of solution, 6.
出处
《贵州化工》
2009年第3期19-22,共4页
Guizhou Chemical Industry
关键词
金银花
提取
绿原酸
Flos lonicerae
extract
Chlorogenic
作者简介
张来新，男，陕西周至人，宝鸡文理化学化工系教授，研究方向：有机合成化学。
