摘要
长期以来，由于对臭氧毒性的顾忌而使其很少用于临床治疗。随着研究的不断深入，目前已经揭示臭氧的毒性／治疗双重作用，其关键就在于所用臭氧的浓度。适当浓度的臭氧能够诱发机体产生一种程度轻微又非常短暂的氧化应激反应，长期反复地接受这种氧化应激反应刺激，可使体内氧化与抗氧化水平重新达到平衡，进而获得良好的临床疗效。而高浓度臭氧所增加的外源性氧自由基超过了体内抗氧化系统的保护能力，则表现出损伤作用。适当浓度的臭氧可以谨慎地用于临床治疗，其应用前景非常广阔。
For a long time, scruple about the toxicity of ozone had restricted its clinical usage. Until now, its dual toxic / therapeutic effect has been well revealed and depends on ozone concentration. With appropriate concentration, ozon may induce a mild and transient oxidative stress response. Such long-term and iterative stimulation helps body to establish a new oxidation/antioxidation balance, exerting favourable therapeutical effects. Once the exogenous oxygen free radical generated from high concentration of ozone overwhelms the endogenous antioxidative ability, deleterious consequences occur.
出处
《国际麻醉学与复苏杂志》
CAS
2009年第3期258-261,共4页
International Journal of Anesthesiology and Resuscitation
关键词
臭氧
氧化应激
抗氧化剂
臭氧耐受
Ozone
Oxidative stress
Antioxidants
Ozone tolerance
