阿托伐他汀对2型糖尿病患者血清脂联素水平及颈动脉内膜中层厚度的影响被引量：19

The effects of atorvastatin on the level of serum adiponectin and carotid intima media thickness in type 2 diabetes mellitus

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摘要目的观察阿托伐他汀对2型糖尿病患者血清脂联素(APN)水平及颈动脉内膜中层厚度(IMT)的影响。方法2型糖尿病患者71例,均在生活方式干预的同时口服降糖药和(或)胰岛素强化治疗,均服用阿司匹林0.1g/d。治疗组在上述治疗基础上每晚加服阿托伐他汀20mg,对照组服用安慰剂,总疗程24周,观察治疗前后血清APN、超敏C反应蛋白(hsCRP)、白介素-6(IL-6)、IMT,并分析IMT与APN、hsCRP、IL-6的相关性。结果与治疗前相比,治疗组治疗后IMT、斑块检出率及hsCRP、IL-6的血清浓度均下降(P<0.05,P<0.01),血清APN浓度明显上升(P<0.01),对照组治疗前、后IMT、APN、hsCRP、IL-6的差异无统计学意义(P>0.05)。治疗前后2组IMT与APN均呈负相关(P<0.01),与hsCRP、IL-6均呈正相关(P<0.01)。结论阿托伐他汀能够升高2型糖尿病患者血清APN水平,降低IMT及血清hsCRP、IL-6,推测阿托伐他汀降低糖尿病患者IMT与改善血管内皮功能及抑制炎性反应有关。 Objective To study the effects of atorvastatin on the level of serum adiponectin（APN） and carotid intima media thiekness（IMT） in type 2 diabetes mellitus （DM）.Methods 71 patients with type 2 DM were recruited in this randomized trial.Based on the intervention of life style,all patients undertook oral antidiabetie drug and/or insulin intensification therapy, and with aspirin 0.1 g/d. The treatment group was added atorvastafin 20 mg every night, while the control group was added the placebo. Course of treatment was 24 weeks. The level of APN, hsCRP, IL-6,IMT was detected before and after treatment, and the correlation between IMT and APN, hsCRP, IL-6 was analyzed. Results In the treatment group, the IMT decreased（ P 〈0.01） after atorvastafin therapy, the detection rate of plaque was degraded（ P 〈 0.05）,and the plasma concentration of APN was upgraded（ P 〈 0.01 ）, while the plasma concentration of hsCRP, IL-6 was even degraded （ P 〈 0.01 ） .In control group,the distinction of IMT,APN,hsCRP,IL-6 between before and after therapy had not statistical significant （ P 〉 0.05）.There was negative correlation between IMT and APN in both groups （ P 〈 0.01）,while the correlation between IMT and hsCRP, IL-6 showed positively （ P 〈 0.01 ）. Conclusion It demonstrated that atorvastatin could help to increase the plasma concentration of APN and decrease the IMT, hsCRP and IL-6 in patients with type 2 DM, probably it improved the function of endothelium and suppressing inflammatory reaction.

作者李桂平李延兵彭娜李绪娴钟思干曾荣辉

机构地区广东省惠州市人民医院内分泌科中山大学第一附属医院内分泌科

出处《疑难病杂志》 CAS 2009年第6期335-337,共3页 Chinese Journal of Difficult and Complicated Cases

关键词阿托伐他汀脂联素超敏C反应蛋白白介素-6 颈动脉内膜中层厚度 2型糖尿病 Atorvastatin Adiponectin High sensitive C-reactive protein Interleukin-6 Carotid intima media thickness Type 2 diabetes mellitus

分类号 R587.1 [医药卫生—内分泌]

作者简介通讯作者：李桂平，E-mail：guiping1@163．com

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参考文献12

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