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DNA氧化性损伤修复酶MTH1及OGG1和MUTYH及其交互作用 被引量：2

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摘要 化学物质在机体内诱导产生活性氧自由基能攻击DNA，主要生成8-羟基鸟嘌呤（7,8-dihydro-8-oxoguanine-8-oxo-Gua），它可导致DNA链空间构象的改变，在DNA复制过程中引起G：C→T：A颠换，形成点突变，该点突变被认为与肿瘤的发生发展、机体细胞的老化和某些退行性疾病均有密切的关系。在哺乳动物细胞中，防止8-羟基鸟嘌呤引起突变的酶的功能逐渐被弄清，
作者 柯跃斌 徐新云 庄志雄 中别府雄作
机构地区 深圳市疾病预防控制中心毒理室 日本九州大学医学院
出处 《中华劳动卫生职业病杂志》 CAS CSCD 北大核心 2009年第5期310-313,共4页 Chinese Journal of Industrial Hygiene and Occupational Diseases
基金 国家自然科学基金（30872149/C1504） 广东省自然科学基金项目f8451802003000336）.
关键词 DNA氧化性损伤 修复酶 交互作用 8-羟基鸟嘌呤 活性氧自由基 哺乳动物细胞 退行性疾病 点突变
分类号 R686 [医药卫生—骨科学]
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参考文献38

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共引文献12

同被引文献20

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中华劳动卫生职业病杂志
2009年 第5期

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