摘要
目的:探讨初次体外受精(in vitro fertilization,IVF)失败后不同时间进行补救单精子卵胞浆内注射(intracytoplasmic sperm injection,ICSI)授精对胚胎发育潜力及妊娠结局的影响。方法:将104例完全不受精或低受精率的常规IVF周期分为6 h后行补救ICSI短时授精组(A组,再将A组按补救ICSI时间分为6～8 h的A1组和8.1～12 h的A2组)及晚时授精(22 h后行补救ICSI)组(B组),比较各组间的治疗结局。结果:A组总的卵裂率、可移植胚胎率、优质胚胎率、妊娠率与B组相比差异显著(P<0.05)。A1组与A2组相比,受精率、卵裂率、可移植胚胎率、优质胚胎率无显著差异,妊娠率差异显著(P<0.05)。结论:缩短卵龄有利于补救ICSI结局的改善。
Objective： To study the effect of rescue or late intracytoplasmic sperm injection （ICSI） on the outcome with different durations after failed fertilization of IVF cycles by intial insemination. Methods： Sixty-four IVF cycles totally or partially failed fertilization were performed rescue ICSI（group A）（AI： 6-8 h and A2：8.1-12 h） after initial insemination, and 40 cycles for late ICSI 22 h later （group B） in this study. Fertilization and cleavage rates, embryo quality, pregnancy rates were compared among these groups. Results： The cleavage rates, available embryo rates, high-qualified embryo rates and pregnancy rates were significantly lower in group B than those in group A （P〈0.05）. The fertilization rates of group A1 was significantly higher than that of group A2. However, no significant differences were found in the rate of cleavage, available embryo, high-qualified embryo between groups A and B （P〉0.05）. Conclusion： Rescue ICSI gives better outcome with reduced oocyte aging.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2009年第5期329-332,共4页
Reproduction and Contraception
基金
973项目(2007CB948103)
江苏省卫生厅项目(2J200606)
关键词
ICSI
补救ICSI
胚胎发育
受精失败
intracytoplasmic sperm injectionrescue（ICSI）
rescue ICSI
embryo development
fertilization failure
作者简介
通讯作者：钱晓乔：E—mail：qian_xiaoqiao@yahoo．com．cn
