摘要
目的研究联素基因SNP+45 T>G在宁夏汉族群体中的基因型频率和等位基因频率。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对101例宁夏汉族人群联素基因SNP+45 T>G分布进行检测。结果宁夏汉族人群中脂联素基因SNP+45TT、TG、GG基因型频率分别为57.42%、39.60%和3.00%,T、G等位基因频率分别为77.23%和22.77%。TT基因型频率和T等位基因频率与北京、黑龙江、安徽、湖北、广东和上海汉族群体相近(P>0.05),高于吉林(37.4%)汉族群体,差异具有统计学意义(P<0.01)。与国外群体比较,中国人SNP+45TT基因型频率和T等位基因频率与韩国人群相近(P>0.05);低于于欧洲的芬兰(89.68%)、希腊(81%)和丹麦(80.87%)人群,差异具有统计学意义(P<0.01)。结论不同种族人群联素基因SNP+45 T>G基因型频率和等位基因频率分布不同,具有其特有的群体遗传学特征。
Objective To study the distribution traits of allele and genotype frequencies of adiponectin gene SNP 45 （T/G） in Ningxia Han nationality. Methods PCR - RFLP method was used to determine the distribution of allele and genotype frequencies of adiponectin gene SNP45（T/G）. Results The genotype frequencies of adiponectin gene SNP 45（T/G） TT, TG, GG were respectively 57.42%, 39.60% and 3.00% ; the frequency T and G allele were respectively 77.23% and 22.77%. The genotype frequency of GG and the frequency G allele were similar to those in Beijing, Heilongjiang, Anhui, Hubei, Guangdong and Shanghai Han nationality （P 〉 0. 05 ）, but which significantly higher than those in Jilin Han nationality （P 〈 0.01 ）. Compared with those in other country, the genotype frequency of adiponectin gene SNP 45（T/G） in Chinese people was similar to that in Korea people, but it was lower than that in Finland （89.68%）, Greece （81%） and Denmark people （80.87%）. Conclusion Different distribution traits of genotype and allele frequencies in adiponectin gene SNP 45（T/G） shows us this single nucleotide polymorphism exist genetics characteristic in different ethnics.
出处
《宁夏医学杂志》
CAS
2009年第5期388-390,共3页
Ningxia Medical Journal
基金
宁夏自然科学基金(A4005)
宁夏医科大学科研项目
关键词
脂联素
基因
单核苷酸多态性
汉族
Adiponectin
Gene
Single nacleotide polymorphism
Han nationality
作者简介
潘琳，女，汉，宁夏籍，在读硕士研究生，主要研究人类群体遗传学。
[通讯作者]霍正浩
