摘要
【目的】观察西藏拉萨地区慢性乙肝患者红细胞免疫功能的变化。【方法】采用萤光定量PCR法(FQ-PCR)检测血清HBV-DNA,采用红细胞C3b受体黏附试验(RBC-C3bRR)、红细胞免疫复合物黏附试验(RBC-ICR)对92例乙肝患者进行HBV-DNA定量及红细胞免疫功能指标检测。【结果】慢性乙型肝炎患者组与HBV-DNA(+)组较HBV-DNA(-)组和对照组RBC免疫黏附活性显著降低(P=0.0112),循环免疫复合物增多,RCIR显著增高(P=0.0431);民族与性别之间红细胞免疫功能比较RCR、RCIR均无显著变化,差异无统计学意义(P=0.302),但年龄之间红细胞免疫功能比较40以上较20岁以下组RCR降低、RCIR升高明显,差异有统计学意义(P=0.039)。【结论】拉萨地区中老年较青少年慢性乙肝患者红细胞免疫功能低下。
Rod blood cell immune function was determined in 92 cases of hepatitis B patients. Fluorecellce quantitive PCR method （FQ-PCR） was used to dated serum HBV-DNA. ROd blood cell adhesion experiment C3b recrptor （PBC-C3Brr） and red blood cell adhesion experimental immune complex （RBC-ICR） were used to detect the immune function. [ Results] The RBC immune adhesion activity in chronic hepatits B group and HBV-DNA （ ＋ ） group were lower than that in HBV-DNA （ - ） group and control group （P = 0. 0112） and circulating immune complex and RCIR were higher （P = 0. 0431 ）. There were no significant sifference between race and gender for RCR and RCIR （ P = 0. 302）. The difference of RCR and RCIR in different age group （4-20 years and 41-67 years） were marked （ P=0.039）. [ Conclusions] In Lhasa area the red blood cell immune function in old aged chronic hepatitis B paatients is decreased.
出处
《武警医学院学报》
CAS
2009年第4期294-296,共3页
Acta Academiae Medicinae CPAPF
基金
武警医学院科研项目(WY2004-15)
天津市科委攻关项目(05YFSZSF02500)
关键词
慢性乙型肝炎
红细胞
免疫功能
Chronic hepatitis B
Red cell
Immtmity function
作者简介
曹占良（1956-），男，本科，副主任技师，主要从事免疫学及输血检验研究。
