摘要
目的检测血管内皮生长因子(VEGF-C)及其受体KDR、Flt-4 mRNA在子宫内膜癌、癌周组织和正常子宫内膜组织的表达,探讨其与子宫内膜癌临床病理参数的关系及意义。方法采用实时荧光定量PCR方法检测62例不同临床分期的子宫内膜癌组织、癌旁组织及51例正常子宫内膜标本中VEGF-C及其受体mRNA水平,分析其与各临床病理参数之间的关系。结果VEGF-C及其受体mRNA在子宫内膜癌组织中的表达明显高于癌周组织(P<0.01),它们在癌周组织中的表达量明显高于高于正常子宫内膜组织(P<0.01)。子宫内膜癌组织中VEGF-C及其受体mRNA的表达水平与肿瘤的临床分期、组织分化程度、肌层浸润深度和有无淋巴结转移明显相关(P<0.01)。结论VEGF-C在子宫内膜癌的发生、侵袭、转移和预后过程中可能起着十分重要的作用,VEGF-C有可能成为治疗子宫内膜癌的一个潜在的分子靶点。
Objective To study the expression and significance of vascular endothelial growth factor-C （VEGF-C） and its receptors, KDR and Flt-4, in endometrial carcinoma. Methods The expressions of VEGF-C,KDR and Flt-4 were detected with real-time quantitative PCR in 62 samples of endometrial cancer and tumor-adjacent tissues and 51 normal endometria. The association between the expressions and the clinicopathologic characteristics of the tumor was analyzed. Results The expression levels of VEGF-C and its receptors were significantly higher in endometrial carcinomas than those in the tumor-adjacent tissues （P〈0.01）, which were higher in the tumor-adjacent tissues than those in the normal endometrias （P〈0.01）. The expression levels of VEGF-C and its receptors were significantly correlated to the clinical stage, grade, invasion and lymphnode metastasis （P〈0.01）. Conclusion The VEGF-C may play an important role in the genesis and development of invasive endometrial carcinoma and might be taken as a potential molecular target in the treatment of endometrial carcinoma.
出处
《江苏医药》
CAS
CSCD
北大核心
2009年第5期531-533,共3页
Jiangsu Medical Journal
关键词
子宫内膜癌
血管内皮生长因子
Endometrial neoplasms
Vascular endothelial growth factor
作者简介
责任作者：王波，E-mail：daisy712_1987@yahoo．com．cn
