摘要
在机体衰老的过程中,会出现2种明显的生理变化即免疫功能衰退和氧化损伤,本文从益生菌的免疫调节作用和抗氧化作用两方面讨论了它们对衰老过程的影响,提出益生菌潜在的抗衰老作用与其抗氧化和免疫调节作用之间存在必然的联系。目前,在部分加速衰老模型中对益生菌抗衰老的研究结果令人鼓舞。本文分析了现在普遍采用的几种衰老评价模型的机制,并指出在筛选和评价益生菌的抗衰老作用时,有必要进一步建立和完善采用与衰老过程相关酶作为靶位酶的体外抗衰老模型,如单胺氧化酶抑制模型或可以反应氧化损伤的细胞模型如Caco-2细胞模型。在此基础上,应用特定的衰老动物模型对体外试验所获得的结果予以验证,以期更客观有效地评价益生菌发挥其抗衰老功效的作用机制。
Two predominant physiological changes would take place during the body aging process,i, e. immunose- nescence and oxidative damage. The effect of immunomodulatory and antioxidant activity of probiotics on aging procedure was discussed and investigated. It was proposed that the potential anti-aging function of probiotics was unquestionably corre- lated with their immune-stimulating and antioxidative activity. Recently, few inspiring studies regarding the anti-aging role of some specific probiotic strains in experimentally senescence-accelerating animals had been reported. The mechanisms of some senescent animal model adopted prevalently at present were also analyzed. It was accentuated that some modified anti- aging screening models engaging key enzyme involved in the aging physiology, e. g. monoamine oxidase which was responsi- ble for the risk of Parkinson disease, as target enzyme in vitro or Caco-2 cells which can reflect the oxidative injures correla- ted with senescence, should be established and improved. Finally, the candidate probiotic strains with potential anti-aging activity should be further assessed in some well-established experimental animal models to verify the results obtained in vitro as well as to elucidate the mechanism of anti-aging activity objectively.
出处
《中国微生态学杂志》
CAS
CSCD
2009年第4期374-379,共6页
Chinese Journal of Microecology
关键词
益生菌
抗衰老
免疫调节
抗氧化
衰老动物模型
体外抗衰老筛选模型
Probiotics
Anti-aging
Immunomodulatory
Antioxidation
Decrepit animal models
Anti-aging screen-ing models in vitro
作者简介
王豪（1984-），男，在读硕士，从事食品生物技术研究；
郭本恒,通讯作者，E-mail：guobenheng@brightdairy．com
